نتایج جستجو برای: ketoglutaric acid
تعداد نتایج: 747478 فیلتر نتایج به سال:
Ammonia toxicity and cerebral oxidative metabolism. Am. J. Physiol. 200(3) : 420-424. 1961. -Effects of NH&l on oxidative metabolism of cat cerebral cortex slices and mitochondria incubated in vitro were studied. In slices, addition of IO mM NH&l to the incubation medium resulted in significant (16%) reduction of O2 uptake, doubling of lactic acid production and marked increase of glucose utili...
The products of L-glutamate fermentation by resting or growing cells of Clostridium tetanomorphum are acetate, butyrate, hydrogen, and approximately stoichiometric amounts of carbon dioxide and ammonia (14). Experiments with C14-labeled glutamate have shown that acetate, butyrate, and carbon dioxide originate preferentially from glutamate carbons 1 and 2, 3 and 4, and 5, respectively, and that ...
Since the dicarboxylic acid system holds a central position in tissue metabolism, the study of possible alterations in this system in the muscles of vitamin E-deficient animals was continued. Transamination between aspartic and a-ketoglutaric acids was investigated because of the many functions which it appears to perform in carbohydrate, fat, and particularly protein metabolism, and in the reg...
It has recently been reported that aluminum plays a very important role in reducing the activity of Krebs-cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Therefore, it is necessary to identify the aluminum binding ability with the pivotal substrate alpha-ketoglutarate in biological systems. The interactions of aluminum with alpha-ketoglutarate were studied with pH-potentiomet...
In the pathway of hydrosyproline metabolism by an inducible strain of Pseudomonas (1)) an initial reaction involves the reversible epimerization of hydroxy-L-proline to allohydroxy-n-proline by racemization at carbon 2. In subsequent steps of this sequence, allohydrosy-n-proline is oxidized to Al-pyrrolinelhydroxy2carboxylate (2) and the latter compound is oxidized to ar-ketoglutarate through a...
An ingenious and specific affinity resin designed to capture the 2-oxoglutaric acid (2-OG) binding proteins was constructed by appending a 2-OG tag to the solid resin via a Cu-catalyzed Huisgen "click" reaction. The so-obtained affinity resin was able to recognize, retain and separate the established 2-OG binding protein NtcA in both the pure form and crude cellular extract, thus constituting a...
Plants inoculated with arbuscular mycorrhizal (AM) fungi utilize more soluble phosphorus from soil mineral phosphate than noninoculated plants. However, there is no information on the response of soil microflora to mineral phosphate weathering by AM fungi and, in particular, on the catabolic diversity of soil microbial communities. The AM fungus, Glomus intraradices was examined for (i) its eff...
INTRODUCTION Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. METHODS In this prospective study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was use...
It is well established that the last step in the biosynthesis of creatine involves the methylation of guanidinoacetic acid.’ This conclusion is based upon experimental evidence derived from two independent lines of investigation. By application of the isotopic tracer technique, du Vigneaud et al. (2) have demonstrated that the methyl group in creatine is derived from L-methionine; furthermore, ...
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