Phototherapy is a safe, effective method for decreasing or preventing the rise of serum unconjugated bilirubin levels and reduces need exchange transfusion in neonates. The aim phototherapy to decrease level order prevent acute encephalopathy, hearing loss kernicterus. Mainly 5 types jaundice- pathological jaundice, physiological breast milk breastfeeding jaundice prematurity. works by 3 proces...

Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been similarly utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulf...

We cared for a term female newborn, who at 108 hours of age, with a total serum bilirubin of 15.4 mg/dL, was discharged from the hospital on home phototherapy. At a return appointment 44 hours later, her total serum bilirubin was 41.7 mg/dL and signs of acute kernicterus were present. Maternal/fetal blood group O/B incompatibility was identified, with a negative direct antiglobulin test, which ...

impression that kernicterus has virtually " become extinct " with the near elimination of Rh disease is incorrect. In fact, this neurological condition is experiencing a re-emergence, likely due to earlier hospital discharge and a " more lax " approach to the treatment of neonatal hyperbilirubinemia. 1 Up to one in 700 healthy term newborns may be at risk of kernicterus due to severe hyperbilir...

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life. Low levels of bilirubin exert antioxidant effects, but some neonates may develop very high levels of unconjugated bilirubin (UCB), with an increase of the unbound free fraction (Bf), able to diffuse through the blood brain barrier. Amount and duration of hyperbilirubinemia and the neurodevelopmental age (...

Neonatal jaundice must have been noticed by caregivers through the centuries, but the scientific description and study of this phenomenon seem to have started in the last half of the 18th century. In 1785 Jean Baptiste Thimotée Baumes was awarded a prize from the University of Paris for his work describing the clinical course in 10 jaundiced infants. The work by Jaques Hervieux, which he defend...