Keloid scar is a fibroproliferative disease caused by aberrant genetic activation of wound healing. The suggested causes keloid pathogenesis include predisposition, upregulation inflammatory cytokines, and most importantly, cellular responses to environmental strains. Although the mechanical stretching has long been postulated as crucial element that leads aggravation pro-fibrotic inflammation ...

Keloid and hypertrophic scars are 2 types of excessive scarring observed clinically that require different therapeutic approaches. The clinical course and physical appearance define keloids and hypertrophic scars as separate entities; however, they are often confused because of an apparent lack of morphologic differences. Nevertheless, clinical differences between hypertrophic scars and keloids...

Many factors go into the complicated process of keloid formation including: inflation, protein formation, and immunoregulators, all of which are influenced in part by certain biomarkers that control these processes at a biochemical level. Although the exact incidence and prevalence of keloids has not been determined, it is reported that the prevalence can be as high as 5 to 16 percent of patien...

Abstract Background Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy triamcinolone acetonide injection is considered be the proper choice for comprehensive treatment of keloids. This study aimed at evaluating therapeutic effect individualize...