The first step in the assembly of new chromatin is the cell cycle-regulated synthesis and nuclear import of core histones. The core histones include H2A and H2B, which are assembled into nucleosomes as heterodimers. We show here that the import of histone H2A and H2B is mediated by several members of the karyopherin (Kap; importin) family. An abundant complex of H2A, H2B, and Kap114p was detect...

Papillomavirus genomes replicate as nuclear plasmids at a low copy number in undifferentiated keratinocytes. Papillomaviruses encode the E1 and E2 proteins that bind to the origin of replication and are required for the activation of replication. In addition to E2, several papillomaviruses express an E8-E2C protein, which is generated by alternative splicing and functions as a transcriptional r...

Proper hydration is essential for both mental and physical performance. The purpose of this study was to determine if hydration education would improve hydration status in collegiate athletes. A total of 120 college athletes, 60 each male and female, 30 each served as the control group (C) and as the intervention (I) group. A pretested questionnaire was used to evaluate the hydration knowledge,...

BACKGROUND This study was conducted to develop a questionnaire in order to evaluate knowledge, attitude and practice (KAP) of the faculty members and students toward plagiarism. METHODS A KAP study was conducted from June to October 2011 enrolling 390 volunteers anonymously (response rate 96%). The questionnaire included the following four parts: (a) general characteristics like gender, acade...

Non-homologous end-joining (NHEJ) and homologous recombination (HR) represent the two main pathways for repairing DNA double-strand breaks (DSBs). During the G2 phase of the mammalian cell cycle, both processes can operate and chromatin structure is one important factor which determines DSB repair pathway choice. ATM facilitates the repair of heterochromatic DSBs by phosphorylating and inactiva...

We intended to assess knowledge, attitude, perception, misconception and views (KAP-MV) of family members of PLWHA. A cross-sectional retrospective study conducted in Anti-retroviral centre of Mahatma Gandhi Memorial-MGM hospital, Warangal, Telangana, South-India from July to September 2014. A questionnaire containing 41 items was distributed among adult family members accompanying patients liv...

This study aims to analyze the effect of forensic accounting, auditor professional skepticism, and audit experience on fraud detection. Data was collected by distributing questionnaires respondents. The population in this are auditors who work a public accounting firm (KAP) Jakarta, with sample 100 auditors. sampling technique used is purposive criteria still actively working at KAP DKI Jakarta...

The consideration of demand variability in Multi-Product Lean Manufacturing Environment (MPLME) is an innovation in production system engineering. Manufacturing systems that fail to recognise demand variability generate high Work-In-Process (WIP) and low throughput in MPLME. In response to demand variability, organisations allocate large quantities of Production Authorisation Cards (PAC). A lar...