couraging results, it was decided to a further extensive trial with this drug in certain hyperendemic kala-azar areas in the tea districts of Mangaldai, as an anti-kala-azar drug of such promising quality was indispensable, especially when, due to present war-time conditions, other pentavalent antimony compounds of proved value, e.g. solustibosan, neostibosan, etc., suitable for mass administra...

Studies with 26 clones of L. donovani promastigotes derived from three different Indian isolates indicated that wild type parasites are mixture of stibanate sensitive and resistant cells. Both forms of the parasite were resistant to the drug. Infection with resistant parasites appears to be the primary reason of high rate of pentavalent antimony unresponsiveness among Indian kala-azar patients....

We report the case of a six-year-old Brazilian girl referred for splenomegaly who first presented with fever, asthenia, and weight loss. Geographical location, clinical exam, and blood laboratories suggested kala-azar. Serology confirmed kala-azar diagnosis, but direct evidence of the parasites was not made. A treatment by meglumine antimoniate is given under hospital surveillance for two weeks...

Dietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. Furthermore, sulforaphane is currently being used in clinical trials to assess its effects against different tumour processes. This study reports an efficient preparation of enantiopure R-sulforaphane based on the enzymatic hydrolysis of its natural precursor glucoraphanin. As an alternative to broccoli seeds, we h...

Only a few cases of Post-kala-azar dermal leishmaniasis have been reported in Japan, especially recently. We describe a case of a 32-year-old woman who developed rose-colored nodules on her forearms two years after Kala-azar. A skin biopsy specimen from a nodule revealed not only granulomatous changes but also many amastigotes of Leishmania donovani in macrophages. Rose-colored nodules were als...

Recently while experimenting with solutions of various dye stuffs on kala-azar serum, we observed that when solutions of methylene blue were left in contact with kala-azar serum, the dye gradually decolourised. We have tried out various strengths of methylene blue solutions varying from 1 in 2,000 to 1 in 80,000 and obtained the most satisfactory results when working with a solution of 1 in 40,...

A comparison of the product yield, total phenolics, total flavonoids, and antioxidant properties was done in different leafy vegetables/herbs (basil, chard, parsley, and red kale) and fruit crops (bell pepper, cherry tomatoes, cucumber, and squash) grown in aeroponic growing systems (AG) and in the field (FG). An average increase of about 19%, 8%, 65%, 21%, 53%, 35%, 7%, and 50% in the yield wa...

Sir,?Major P. Savage, i.m.s., in the June number of your journal lias recorded the apparent occurrence of indigenous kala-azar at Sanawar in the Simla Hills, where up to that time the presence of Phlcbotomus argcntipcs, the suspected carrier of kala-azar, had not been reported. It is, therefore, of interest to note that in a collection of Phlcbotomus from Sanawar village, kindly given me by Cap...

Antigenic characterization of the soluble fraction of axenic amastigotes of Leishmania donovani ( strain Dd8, causative agent of Indian kala-azar) and their comparison with promastigotes is reported. The axenic amastigotes were assessed for their immunological status employing anti-A2 monoclonal antibody which is extremely specific for L. donovani amastigotes. SDS-PAGE of 35[S] methionine label...

The immunological mechanisms underlying the susceptibility to disseminated visceral parasitism of mononuclear phagocytes in patients with kala-azar remain undefined. Resistance and susceptibility are correlated with distinct patterns of cytokine production in murine models of disseminated leishmanial disease. To assess lesional cytokine profiles in patients with kala-azar, bone marrow aspirates...