...................................................................................................................... iii ACKNOWLEDGMENTS ................................................................................................. vi TABLE OF CONTENTS ................................................................................................. viii LIST OF TABLES ........................

Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with well-differentiated squamous cell carcinoma (SCC). An increased incidence of both KA and non-melanoma skin tumor, including SCC, is seen among immunosuppressed, organ-transplant recipients. In this report we describe a case of KA accompanied by multiple lung SCCs develo...

In the histopathological diagnosis of cutaneous tumors, the differential diagnosis of squamous cell carcinoma (SCC) with crateriform architecture and keratoacanthoma (KA) is often difficult so an accurate understanding of the biological features and the identification of reliable markers of SCC and KA are crucial issues. Insulin-like growth factor 2 mRNA-binding protein-3 (IGF2BP3, also known a...

BACKGROUND Gamma-aminobutyric acid (GABA) and glutamate (GLU) are involved in nociceptive signals processing in the trigeminal system. In this study, we investigated the influence of excitatory transmission on GABA release in nerve terminals isolated from the rat trigeminal caudal nucleus (TCN). METHODS We utilize biochemical (superfused synaptosomes loaded with [(3) H]GABA) and morphological...

The Great Khingan Mountain range, Northeast China, is located on the northern limit of modern East Asian Summer Monsoon (EASM) and thus highly sensitive to the extension of the EASM from glacial to interglacial modes. Here, we present a high-resolution pollen record covering the last glacial maximum and the early Holocene from a closed crater Lake Moon to reconstruct vegetation history during t...

Here we present multi-proxy data from two cores taken from Hundred Mile Lake in the Matanuska Valley of south-central Alaska to investigate the climate, vegetation and deglaciation history of the last 14,000 years. The chronology of the cores was controlled by five AMS dates. Sediment lithology changes from clay at 14–13 ka (1 ka 1⁄4 1000 cal BP), through marl at 13–8 ka, to gyttja at 8–0 ka. T...

LPD from Taiwan health care payer’s perspective. Methods: A Markov was designed to simulate outcomes of two options in a hypothetical cohort of adult CKD patients with eGFR 15-29 mL/min/1.73m2: (1) Initiation of LPD plus KA, and (2) watchful-waiting on LPD and initiation of KA at eGFR < 15 mL/min/1.73m2. The Markov states included CKD stage 4 and 5, hemodialysis, and death. Total direct medical...