Approximately 8 million people worldwide are infected by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. After a latent period that can last years or decades, 10% to 30% of infected people develop serious complications, such as cardiomyopathy or gastrointestinal dysfunction. Contrary to popular belief, Chagas disease is not solely a vector-borne infection of Lat...

We thank Drs Phillips and Senaratne for their inquiry about the potential association of non-alcoholic fatty liver disease (NAFLD) in pregnancy with intrahepatic cholestasis (ICP) our study cohort.[1]Sarkar M. Grab J. Dodge J.L. Gunderson E.P. Rubin Irani R.A. et al.Non-alcoholic is associated adverse maternal perinatal outcomes.J Hepatol. 2020; 73: 516-522Abstract Full Text PDF PubMed Scopus (...

Program Number: 5968 Poster Board Number: A0139 Presentation Time: 12:00 PM–1:45 PM In vivo two-photon fluorescence kinetics of primate rods and cones during light and dark adaptation Robin Sharma1, 2, Christina Schwarz2, Grazyna Palczewska3, Krzysztof Palczewski4, David R. Williams1, 2, Jennifer J. Hunter5, 2. 1The Institute of Optics, University of Rochester, Rochester, NY; 2Center for Visual...

Fro Me Ins Pe Lis Yo Ma The cardiovascular science community has pursued the quest to identify vulnerable atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events. However, despite major advancements in imaging technology that allow visualization of rupture-prone plaques, clinical studies have not demonstrated improved risk prediction compared with traditional app...

Purpose: Therapeutic strategies to enhance the efficacy of radioimmunotherapy have not been explored. Motexafin gadolinium is a novel anticancer agent that targets redox-dependent pathways and enhances sensitivity of tumor cells to ionizing radiation. Experimental Design:We did preclinical studies examining motexafin gadolinium combined with rituximab and/or radiation in lymphoma cells. We subs...

Oral antidiabetic drugs (OADs) are widely used to treat type 2 diabetes mellitus (T2DM). However, inherited difference is one of the major issues that affect OADs therapeutic efficacy. In the present paper, we performed a critical review on recent advances in genetic polymorphisms that influence OADs therapeutic efficacy and metabolism. Sulfonylureas (SUs), Meglitinides, Metformin and Thiazolid...

This paper analyzes the impact of bureaucratic decision costs on agency expertise. The analysis shows that the effect of the cost associated with adopting a new regulation (the “enactment cost”) on agency expertise depends on what the agency would do if it remains uninformed. If an uninformed agency would regulate, increasing enactment costs increases agency expertise; if an uninformed agency w...

One of the most efficient non-destructive techniques for finding hidden faults in a plate is the use of ultrasonic Lamb waves. These waves are reflected by faults, and from this reflection, we can locate the faults. For that, we need to know how the Lamb waves propagate. Their propagation is determined by the dynamic elastic constants C 0 pq , so we must find these constants. These constants ca...

Leukotrienes have been implicated to play a prominent inductive role in carcinogenesis. We previously reported that bronchoalveolar lavage (BAL) cells from smokers manifested higher levels of leukotriene B4 (LTB4) production than ex-smokers. This study aims to elucidate the underlying mechanism(s). BAL cells from current and former smokers were exposed to lipopolysaccharide (LPS) for up to 7 da...