In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK) target genes Jra and chickadee. ATAC subunits are required for c-Jun occupan...

Abstract The monsoon trough and subtropical high have long been acknowledged to exert a substantial modulating effect on the genesis development of tropical cyclones (TCs) in western North Pacific (WNP). However, potential upscaling TCs large-scale circulation remains poorly understood. This study revealed considerable contributions climate mean state variability WNP between 1958 2019, characte...

OBJECTIVE 1) To assess the quality of life (QOL) in children with obstructive sleep apnea (OSA) compared with QOL of children with chronic medical conditions, and 2) To determine QOL in children with OSA after adenotonsillectomy in short- and long-term follow-up. DATA SOURCES/REVIEW METHODS: A literature review on QOL in pediatric OSA using the PubMed database. RESULTS The literature search y...

OBJECTIVE To compare polysomnography (PSG) and self-reported sleep, symptoms (pain and fatigue), and anxiety between children with active and inactive juvenile rheumatoid arthritis (JRA) and examine relations among sleep, symptoms, and anxiety. METHODS Two consecutive nights of PSG, self-reported sleep, and symptoms were obtained in 70 children 6-11 years of age with active (n = 35) or inacti...

T IS RECOGNIZED that tests for rheumaI toid factors are less often positive in juvenile rheumatoid arthritis (JRA) than in the adult form of the disease. The explanation for this discrepancy is not completely clear. Those children who develop seropositivity may constitute a separate group of patients from the standpoint of diagnosis or prognosis. Ideally, to ascertain this, children with arthri...

Tumour necrosis factor (TNF) plays a central part in the pathophysiology of rheumatoid arthritis (RA). TNF initiates signal transduction by interacting with surface bound TNF receptors. Soluble tumour necrosis factor receptors (sTNFRs) act as natural inhibitors of TNF activity. Etanercept, recombinant p75 sTNFR:Fc fusion protein, has received approval from the US Food and Drug Administration fo...

OBJECTIVE To uncover the specificities of autoantibodies to nuclear proteins (ANA) in patients with juvenile rheumatoid arthritis (JRA). METHODS Peptide ligands for ANA were selected by panning random peptide phage display libraries on antibodies binding to HEp-2 cells. Positive phage clones were identified by the immunoscreening technique. RESULTS Groups of peptides were identified, some o...

Tumour necrosis factor (TNF) is an important inflammatory disease mediator in a wide spectrum of articular diseases, including adult and juvenile rheumatoid arthritis (RA, JRA). Etanercept (Enbrel), approved in the United States and in Europe for use in patients with RA and JRA, is an effective inhibitor of TNF that has been shown to provide rapid and sustained improvement in both of these dise...

SIR, Immune complexes (IC) are believed to play a role in the pathogenesis of juvenile rheumatoid arthritis (JRA) w1x. Their prevalence varies from 39 to 79% depending on the method used for their detection w2x. Immunoglobulin M (IgM)and IgG-containing IC activate the classical complement pathway, whereas IgA-containing IC activate an alternative complement pathway. Several groups, including ou...

Atmospheric rivers, or long but narrow regions of enhanced water vapor transport, are an important component the hydrologic cycle as they responsible for much poleward transport and result in precipitation, sometimes extreme intensity. Despite their importance, uncertainty remains detection atmospheric rivers large datasets such reanalyses century scale climate simulations. To understand this u...