Large scale traffic congestion often stems from local traffic jam in single road or intersection. In this paper, macroscopic method was used to explore the formation and propagation of local traffic jam. It is found that (1) the propagation of traffic jam can be seen as the propagation of traffic signal parameters, that is, virtual split and virtual green time; (2) for a road with endogenous fl...

Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)-B and Jam-C, membrane type 1-matrix metalloproteinase (MT1-MMP), and integrin alpha(2)beta(1), which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockade of both Jam-B and Jam-C using antibodies, siRNA, or dominant-negative mutants completely...

Monocyte recruitment from the vasculature involves sequential engagement of multiple receptors, culminating in transendothelial migration and extravasation. Junctional adhesion molecule-C (JAM-C) is localized at endothelial intercellular junctions and plays a role in monocyte transmigration. Here, we show that blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compar...

The junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein, which belongs to the immunoglobulin superfamily (IgSF). JAM-B is localized to cell-cell contacts and enriched at cell junctions in epithelial and endothelial cells, as well as on the surface of erythrocytes, leukocytes, and platelets. Recent research in this field has shown that JAM-B plays an important role ...

Background Each year breast cancer is diagnosed in approximately 1 million women worldwide [1]. Our lab has previously linked Junctional Adhesion Molecule A (JAM-A) gene and protein over-expression in breast tumours with an increased risk of metastasis [2,3]. JAM-A loss or inhibition has also been shown to inhibit cell migration and invasion [2], while increasing apoptosis possibly as a result ...

A detailed study is undertaken of the v{max}=1 limit of the cellular automaton traffic model proposed by Nagel and Paczuski [Phys. Rev. E 51, 2909 (1995)]. The model allows one to analyze the behavior of a traffic jam initiated in an otherwise freely flowing stream of traffic. By mapping onto a discrete-time queueing system, itself related to various problems encountered in lattice combinatoric...

In Japan, the continual rise in the number of people moving to Tokyo is causing various economic and social problems, including high o&e rents, housing shortages, trafic jams, and obligatory long-distance commuting. To try to curb this concentration in Tokyo, government agencies and private companies have set up projects and research groups to study distributing ofice space. We have been studyi...

Game jams are social events involving the integration of enthusiasts from various game making disciplines (e.g. programming, art, design) to make games under constraints, such as a short fixed time (Goddard et al. 2014) and a common theme (Fowler et al 2013). Research on game jams has suggested that they have the potential to provide an effective and focused experience and that participants gai...

This paper investigates handover and fresh call blocking probabilities for subscribers moving along a road in a traffic jam passing through consecutive cells of a wireless network. It is observed and theoretically motivated that the handover blocking probabilities show a sharp peak in the initial part of a traffic jam roughly at the moment when the traffic jam starts covering a new cell. The th...

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this response remain largely unknown. We have previously shown that neutrophils can exhibit abluminal-to-luminal migration through EC junctions within mouse cremasteric venules and that this response is elicited following reduced exp...