Sir, Hypoglycaemia is a well-recognised feature of paracetamol overdose, after the development of fulminant hepatic failure, but we are aware of only one previous description of hyperglycaemia and that was in a patient with a family history of diabetes mellitus.' Over recent months we have seen five patients, all male, aged 17 to 40, who have had random blood sugars of 7.2-12.8 mmol/l (mean 9.1...

Background: Pain due to open cholecystectomy can result in delayed recovery and poor operative outcomes. Multimodal approaches pain control cause functional improvement. We compared the efficacy of paracetamol 1 g, dexamethasone 8 mg, magnesium sulfate 2 g with normal saline over perioperative hemodynamics post-operative patients undergoing under general anesthesia. Aims Objectives: This study ...

Simultaneous spectrophotometric determination of salicylamide and paracetamol by H-point standard addition method (HPSAM) and partial least squares (PLS) calibration is described. The results showed that simultaneous determinations could be performed with the ratio 0.2:5–20:1 for salicylamide – paracetamol. A partial least – squares multivariate calibration method for the analysis of binary mix...

1. The metabolism of [3H]paracetamol has been studied in the perfused rat kidney. Seventy-four per cent of filtered paracetamol was reabsorbed. Paracetamol appeared in the urine; 90% was unaltered but 10% appeared as metabolites: the glucuronide, sulphate, mercapturic acid and cysteine conjugates. 2. At concentrations of paracetamol of 1--3 mmol/l no impairment of renal physiological function w...

Benign Prostatic Hyperplasia (BPH) merupakan keadaan kondisi terjadinya penyumbatan yang terlihat pada pembesaran prostat jinak dengan tampilan histologis adenoma menyebabkan obstruksi bervariasi atau tanpa gejala. Kejadian komplikasi biasa ditimbulkan oleh BPH adalah sistitis dan anemia. Pembesaran jaringan tinggi akan penekanan uretra pars prostatika lumen mengakibatkan obstruksi. Tujuan: unt...

Paracetamol has recently been suggested to affect emotion processing in addition to alleviating pain in humans. We investigated in adult male Hannover-Wistar rats whether acute intraperitoneally administrated paracetamol affects behavior in tests measuring anxiety, mood, motor activity, and memory. Unoperated rats received saline or a low (50 mg/kg) or high (300 mg/kg) dose of paracetamol, whil...

The rate of paracetamol absorption depends on the rate of gastric emptying. Propantheline delayed gastric emptying and markedly slowed the absorption of paracetamol in six convalescent hospital patients. Conversely, the absorption of paracetamol in five healthy volunteers was accelerated by metoclopramide, a drug which stimulates gastric emptying. The total 24-hour urinary excretion of paraceta...

After a brain injury, raised temperature may be due to a regulated readjustment in the hypothalamic 'set-point' in response to inflammation. The purpose of this report is to mention possible implications related to temperature and homeostasis of morphine treatment in a patient with brain injury. During the month previous to her hospitalization in our city she was treated for fever with paraceta...

INTRODUCTION In this study, we aimed to examine the association between paracetamol administration in the intensive care unit (ICU) and mortality in critically ill patients. METHODS We conducted a multicenter retrospective observational study in four ICUs. We obtained information on paracetamol use, body temperature, demographic, clinical and outcome data from each hospital's clinical informa...