Isoflavonoid contents of different plant parts and callus tissues of the Indian Kudzu, Pueraria tuberosa (Roxb.ex.Willd.) DC are presented. The initial cultures were slow growing, associated with browning of the tissues. The production of four isoflavonoids (puerarin, genistin, genistein and daidzein) in the callus cultures of P. tuberosa was studied by manipulating the plant growth regulators ...

Brown rice (BR) and germinated brown (GBR) of Oryza sativa L. are popularly consumed by Asians because their important healthy diet components. They known to contain bioactive compounds nutrients, such as phenolics, vitamins, fatty acids, sugars, which help maintain good health reduce the incidences various chronic diseases. The objective this study was investigate effects germination on change...

Pueraria mirifica is a popular medicinal plant and rich in phytoestrogens, especially isoflavonoids. The chalcone isomerase (CHI) gene well-known as key factor biosynthetic pathways such flavonoid, isoflavonoid, anthocyanin biosynthesis. Among four CHI subfamilies, group IV remained largely uncharacterized P. mirifica. By isolation cloning, the CHI4A was amplified sequenced. A dataset that incl...

Kakkalide is a major isoflavonoid from the flowers of Pueraria lobata (Willd.) Ohwi, possessing the protective effect against ethanol-induced intoxication and hepatic injury. The metabolism of kakkalide was investigated in rats. Thirteen metabolites were isolated by using solvent extraction and repeated chromatographic methods and identified by using spectroscopic methods including UV, IR, mass...

Malignant neuroblastomas mostly occur in children and are frequently associated with N-Myc amplification. Oncogene amplification, which is selective increase in copy number of the oncogene, provides survival advantages in solid tumors including malignant neuroblastoma. We have decreased expression of N-Myc oncogene using short hairpin RNA (shRNA) plasmid to increase anti-tumor efficacy of the i...

Isoflavones comprise a group of phytoestrogenic polyphenols with antioxidant properties occurring especially in plants of the Leguminosae family, and are consumed by humans mostly in form of soy (Glycine max (L.) Merr.) and products. Soy rich isoflavone products have been promoted recently as foods or supplements with functional or nutraceutical characteristics, especially for the prevention of...

DNA topoisomerase I from Plasmodium falciparum (PfTopoI), a potential selective target for chemotherapy and drug development against malaria, is used here, together with human Topo I (HssTopoI), for docking, molecular dynamics (MD) studies and experimental assays. Six synthetic isoflavonoid derivatives and the known PfTopoI inhibitors camptothecin and topotecan were evaluated in parallel. Theor...

Seventeen isoflavonoids from isoflavone, isoflavanone and isoflavan classes are selected from Dalbergia parviflora. The ChEMBL database is representative from these molecules, most of which result highly drug-like. Binary rules appear risky for the selection of compounds with high antioxidant capacity in complementary xanthine/xanthine oxidase, ORAC, and DPPH model assays. Isoflavonoid structur...