Abstract Isoflavones possessing several weak acidic hydroxyl groups can undergo successive deprotonations in aqueous solutions. Therefore, their antioxidant properties cannot be ascribed only to the neutral forms but also corresponding phenoxide anions. It was already confirmed that isoflavones prefer formation of dianions solution. For eight and preferred (poly)deprotonated forms, thermochemis...

Ergot alkaloids produced by a fungal endophyte (Epichloë coenophiala; formerly Neotyphodium coenophialum) that infects tall fescue (Lolium arundinaceum) can induce persistent constriction of the vasculature in ruminants, hindering their capability to thermo-regulate core body temperature. There is evidence that isoflavones produced by legumes can relax the vasculature, which suggests that they ...

Isoflavones are excreted in human urine and can be modulated by soy-rich diets. Recently, isoflavones were suggested to have protective effects against bladder cancer cells. We sought to determine the efficacy of the antitumorigenic effects of isoflavones at concentrations found in the range of human urine excretion and compare normal urothelium and bladder cancer cells for differential cytotox...

BACKGROUND Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease. OBJECTIVE Our aim was to investigate the effects of isolated soy isoflavones on inflammatory ...

Functional Feeds It is well known that the value of clover is in nitrogen. Clovers fix their own nitrogen so that an input of nitrate fertilizer is not required. Furthermore, they are rich in protein-nitrogen, and can be used to meet the protein requirements of ruminants. Clovers also contain a class of chemicals called isoflavones, and we have recently discovered evidence that the isoflavones ...

Isoflavones occurring in soybean seed have been thought to have a positive effect on the health of humans, especially in cancer prevention. This positive impact may be a result of their antioxidant properties, estrogenic activity, or a combination of mechanisms. The purpose of this study was to quantify and compare different levels of isoflavones in various Kansas soybean cultivars. Seeds of fo...

The inhibitory activity of 3 soy isoflavones (daidzein, genistein and glycitein) and their glycosides (daidzin, genistin and glycitin) on mammalian DNA polymerases (pols) and topoisomerases (topos) was investigated. Of the compounds tested, only genistein selectively inhibited human topo II activity and had an IC50 value of 37.5 µM. These isoflavones had no effect on the activity of human topo ...

In this study, analytical and preparative HPLC systems were utilized to obtain isoflavones from Korean soybean. The mobile phases were the ternary system of water/acetonitrile/acetic acid. The optimum operating conditions were experimentally determined with the analytical column (C18, 0.46x25 cm 5 micron and the preparative column packed with 15 micron. The experimental variables were the gradi...

Soy isoflavones, the focus of much research and controversy, are often referred to as "weak estrogens". In fact, genistein is a relatively potent agonist for the recently characterized beta isoform of the estrogen receptor (ERbeta). The low nanomolar serum concentrations of unconjugated free genistein achieved with high-nutritional intakes of soy isoflavones are near the binding affinity of gen...