نتایج جستجو برای: ischemia reperfusion injury

تعداد نتایج: 381181  

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Yasushi Sakata Jian-Wen Dong Jesus G Vallejo Chien-Hua Huang J Scott Baker Kevin J Tracey Osamu Tacheuchi Shizuo Akira Douglas L Mann

Production of proinflammatory cytokines contributes to cardiac dysfunction during ischemia-reperfusion. The principal mechanism responsible for the induction of this innate stress response during periods of myocardial ischemia-reperfusion remains unknown. Toll-like receptor 2 (TLR2) is a highly conserved pattern recognition receptor that has been implicated in the innate immune response to a va...

Journal: :Turkish journal of clinics and laboratory 2021

Aim: Acute myocardial infarction is a major cause of morbidity and mortality worldwide. Although thrombolytic therapy primary percutaneous coronary intervention are the therapeutic approaches to reduce ischemic injury limit infarct size by providing reperfusion, process can itself induce cardiomyocyte death known as reperfusion injury. In addition effects on immunsuppression for organ transplan...

Journal: :The Chinese journal of physiology 2011
Li-Jun Cao Jin Wang Pan-Pan Hao Chun-Li Sun Yu-Guo Chen

Established therapies for cerebral ischemia-reperfusion injury are currently limited. The urinary trypsin inhibitor ulinastatin (UTI) is considered cytoprotective against ischemia-reperfusion injury in internal organs through its anti-inflammatory activity. We aimed to investigate the neuroprotective effects of UTI on learning and memory of rats after cerebral ischemia-reperfusion injury. Rats ...

Ali Akbar Nekooeia Gholam Abbas Dehghani Hamdolah Panahpour

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...

2012
Aijiao Xiao Rixin Chen Mingfei Kang Shenghai Tan

Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui (DU14) for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical my...

Journal: :international journal of preventive medicine 0
maryam moeini mehdi nematbakhsh mohammad fazilati ardeshir talebi ali asghar pilehvarian fariba azarkish

background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...

Journal: :avicenna journal of phytomedicine 0
mahdi esmaeilizadeh physiology research center, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran mahin dianat physiology research center and department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran mohammad badavi physiology research center and department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran alireza samarbaf-zadeh department of virology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran bahareh naghizadeh department of pharmacology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

objective: oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. this study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin e by the enos and inos express gene in ischemia/reperfusion in rats. material & methods: male rats were divided into seven groups, namely: sham, control group and ex...

2014
Yantao Liu Liqun Yang Kunming Tao Marcela P Vizcaychipi Dafydd M Lloyd Xuejun Sun Michael G Irwin Daqing Ma Weifeng Yu

BACKGROUND The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI. METHO...

2015
Kyoko Ueda Fumio Tsuji Tomoko Hirata Kenji Ueda Masaaki Murai Hiroyuki Aono Masanori Takaoka Yasuo Matsumura

Tumor necrosis factor (TNF)-α plays a crucial role in the pathogenesis of ischemia/reperfusion-induced renal injury. We demonstrated recently that the preischemic treatment with resiniferatoxin, a transient receptor potential vanilloid 1 (TRPV1) agonist, attenuates renal TNF-α mRNA expression, and improves ischemia/reperfusion-induced renal injury in rats. In the present study, we investigated ...

Journal: :International journal of clinical and experimental medicine 2014
Meng Shi Jiechun Huang Liewen Pang Xiaotian Sun Xianglin Chu Rongrong Jang Xiaolin Xu Yiqing Wang

OBJECT To investigate the effect of lung Ischemia-reperfusion injury on cardiac muscle. METHODS SD rats were randomly divided into the following four groups: sham operation group (TS group); experimental control group (TG group); curcumin group (TC group); dexamethasone group (TM group). After 4 h and 24 h of lung ischemia-reperfusion, the cardiac muscle was collected. We measured the concent...

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