Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...

Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...

Aim: Our aim was to investigate expression level of VEGF in tuba uterine ovarian ischemia-reperfusion (I/R) by immunohistochemical techniques. Material and Methods: 30 Sprague Dawley female rats were categorized into three groups. Sham group: The abdomen opened closed without any treatment. Ischemia (I) 1-hour ischemia allowed create ischemic injury. Ischemia-reperfusion then 3-hour reperfusion...

Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. Materials and Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induce...

Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.  Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...

Objective: Ischemia-reperfusion (I-R) injury is defined as the paradoxical exacerbation of cellular dysfunction and death following restoration blood flow to ischemic tissues. In our study, it was aimed examine potential DNA effects liver IR with an experimental animal model. Material Methods: modeling done seven male New Zealand rabbits. Blood samples were taken before model, 30 minutes after ...

Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distil...

background: brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. methods: the possible therapeutic potential of human umbilical cord blood (hucb) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. seven days after hypoxia-ischemia, rats received either saline ...

objective(s): to evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (ir) injury. materials and methods: eighteen female wistar albino rats were used in control, ir, and ir+edosteine (ir-e) groups, (n=6 in each). the ir-e group received the erdosteine for seven da...