Complexation is very relevant in pharmacy as a means of modifying the pharmacological, toxicological and physicochemical properties of drugs.In this study, iron (III) complexes of ciprofloxacin, ampicillin, amoxicillin, and cloxacillin were synthesized through systematic choice of solvents and reaction conditions. A Schiff base derived from Isatin (Indole-1,2-dione) and ethylenediamine, and its...

The work described here comprises the determination of Fe(III) by ion selective potentiometry using a coated-wire ion-selective electrode (CWISE) based on iron–cyclam complex. Linear Nernstian response for this electrode was obtained over the total Fe(III) concentration range of 1× 10−2 to 1× 10−6 M in 0.05 M HNO3, H2SO4, HClO4, HCl, KNO3 and KCl media, with a slope of 60± 5 mV per decade chang...

The influence of water on the interaction between iron(III) and indole-3-acetic acid (IAA) was studied in different organic solutions using rapid-scan stoppedflow spectrophotometry and rapid-freeze/quench Mössbauer spectroscopy. Measurements were also performed in ethanol– water and acetone–water mixtures. The results showed that the interaction between Fe and IAA resulted in dimeric Fe–IAA com...

A triptycene-based bis(benzoxazole) diacid ligand H(2)L2(Ph4) bearing sterically encumbering groups was synthesized. Treatment of H(2)L2(Ph4) with Fe(OTf)(3) afforded a C(2)-symmetric trinuclear iron(III) complex, [NaFe(3)(L2(Ph4))(2)(μ(3)-O)(μ-O(2)CCPh(3))(2)(H(2)O)(3)](OTf)(2) (8). The triiron core of this complex adopts the well known "basic iron acetate" structure where the heteroleptic car...

The use of Porphyrin derivatives as photosensitizers in Photodynamic Therapy (PDT) was investigated by means of a molecular docking study. These molecules can bind to intracellular targets such as P-type CaCa(2+) ATPase of sarcoplasmic reticulum (SERCA1a). CAChe software was successfully employed for conducting the docking of Tetraphenylporphinesulfonate(TPPS), 5,10,15,20- Tetrakis (4-sulfonato...

We report the results from an ASCA observation of the high-luminosity, radio-loud quasar PKS 2149-306 (redshift 2.345), covering the approximately 1.7-30 keV band in the quasar frame. We find the source to have a luminosity approximately 6x1047 ergs s-1 in the 2-10 keV band (quasar frame). We detect an emission line centered at approximately 17 keV in the quasar frame. Line emission at this ene...

Iron is an essential element for all organisms, and microorganisms produce small molecule iron-chelators, siderophores, to efficiently acquire Fe(III). Gram-positive bacteria possess lipoprotein siderophore-binding proteins (SBPs) on the membrane. Some of the SBPs bind both apo-siderophores (iron-free) and Fe-siderophore (iron-chelated) and only import Fe-siderophores. When the SBP initially bi...

Iron (III) phosphate catalyzed condensation reaction of aldehydes, 1,3-dicarbonyl compounds and amuniom acetate refluxing ethanol that remains a common theme in current literature.

While iron-catalyzed Kumada cross-coupling reactions with simple iron salts have been known since the early 1970s, the nature of the in situ-formed iron species remains elusive. Herein, we report the synthesis of the homoleptic tetralkyliron(III) ferrate complex [MgCl(THF)5][FeMe4] from the reaction of FeCl3 with MeMgBr in THF. Upon warming, this distorted square-planar S = (3)/2 species conver...

The present work describes a research approach to the anaerobic bioleaching of Fe(III) ores. Three strains (Serratia fonticola, Aeromonas hydrophila and Clostridium celerecrescens) isolated from an acidic abandoned mine were selected to test their ability to reduce dissimilatory Fe(III). Total iron bio-reduction was achieved after 48 h using either the consortium or the Aeromonas cultures. In t...