Abnormally high deposition of iron can contribute to neurodegenerative disorders with cognitive impairment. Since previous studies investigating cognition-brain iron accumulation relationships focused on elderly people, our aim was to explore the association between iron concentration in subcortical nuclei and two types of memory performances in a healthy young population. Gender difference was...

4 Mineral aerosol deposition is recognized as the dominant source of iron to the open 5 ocean and solubility of iron in the dust aerosol is highly uncertain. Previous solubility 6 estimates range widely from 0.01-80%. We developed two conceptual models to solve 7 for the solubility of different particle sizes—diffusion-controlled model and surface8 controlled model. We are able to produce time ...

BACKGROUND AND PURPOSE Hyperpermeability and iron deposition are 2 central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here, we used 2 novel MRI techniques to establish a relationship between these phenomena. METHODS Subjects with CCM disease (4 sporadic and 17 familial) underwent MRI imaging using the dynamic contrast-enhanced quantitative perfusion a...

A global ocean biogeochemical model is used to quantify the sensitivity of marine biogeochemistry and air–sea CO2 exchange to variations in dust deposition over decadal timescales. Estimates of dust deposition generated under four climate states provide a large range in total deposition with spatially realistic patterns; transient ocean model experiments are conducted by applying a step-functio...

Background Ferric carboxymaltose (FCM) is a stable, non-dextran-based intravenous iron complex used to treat iron deficiency of various etiologies. As FCM is a nonbiological complex drug and cannot be fully characterized by physicochemical analyses, it is important to demonstrate in nonclinical models that FCM similars (FCMS) have similar biodistribution. Materials and methods A total of 30 n...

[1] Mesoscale anticyclonic Haida eddies are proposed to deliver a substantial amount of iron into the Gulf of Alaska (GOA) central gyre, where surface waters experience high‐nitrate low‐chlorophyll conditions. In this study we calculate an averaged upwelling flux of dissolved iron into the euphotic zone (100 m) of 1.17 mmol m d based on observed iron profiles and modeled eddy dynamics and resul...

Increased iron deposition might be implicated in multiple sclerosis (MS). Recent development of MRI enabled to determine brain iron levels in a quantitative manner, which has put more interest on studying the role of iron in MS. Evidence for abnormal iron homeostasis in MS comes also from analyses of iron and iron-related proteins in CSF and blood and postmortem MS brain sections. However, it i...

Hemosiderinuria caused by intravascular hemolysis is a characteristic clinical feature of an acquired hemolytic disorder, paroxysmal nocturnal hemoglobinuria (PNH). We examined the deposition of hemosiderin (iron) in the kidneys of 6 patients with PNH using magnetic resonance imaging (MRI). Three patients with autoimmune hemolytic anemia (AIHA), a hemolytic disorder showing extravascular hemoly...

The corrosion resistance of electroless nickel (EN) coatings on ferrous substrates is affected by coating porosity. Carbon and iron carbide are present in the microstructure of ferrous alloys. If the sites of carbon and iron carbide are not catalytically active to EN deposition as the rest of substrate surface, there is a possibility of pore formation on these sites. In the present study, the r...

BACKGROUND Pantothenate kinase-associated neurodegeneration (PKAN), sickle cell anemia, and thalassemia are autosomal recessive disorders that can cause iron deposition in tissues during childhood. PKAN is characterized by accumulation of iron in the basal ganglia causing progressive extrapyramidal manifestations. Thalassemia and sickle cell disease can cause iron overload and deposition in tis...