Ocular neovascularization (NV) is the primary cause of blindness in many ocular diseases. Large molecular weight anti- vascular endothelial growth factor (VEGF) protein drugs, such as Avastin and Lucentis, have saved the vision of millions. However, approximately 20-30% of patients respond poorly to anti-VEGF treatment. We found that artesunate (ART), a small molecular derivative of artemisinin...

PURPOSE To examine the intraocular distribution of bevacizumab at four weeks after intravitreal bevacizumab (IVB) injection and to investigate the effects of IVB on apelin and vascular endothelial growth factor (VEGF) in the central retinal vein occlusion (CRVO) of monkey eyes. METHODS Direct laser coagulation was performed on all branch retinal veins in the right eyes of six Rhesus monkeys t...

A healthy 12 month old infant without significant medical history presented with left eye redness for one week. Ophthalmic examination showed elevated intraocular pressure with iris neovascularization in the affected eye with increased optic nerve cupping. Scleral depression revealed a ciliary body mass in the supratemporal quadrant. A large, non-pigmented, vascular mass was noted; biopsy resul...

A 34-year-old female with Usher syndrome, but no family history of similar illness, presented with complaints of vision reduction, redness, and photophobia. Biomicroscopic examination showed mildly injected conjunctivae bilateral, small, round keratic precipitates; bilateral +2 cells with no flare reaction in the anterior chamber; and bilateral posterior subcapsular cataracts. No associated pos...

OBJECTIVE To evaluate the results of thermotherapy for retinoblastoma. DESIGN Prospective, nonrandomized analysis of the treatment method. PARTICIPANTS A total of 188 retinoblastomas in 80 eyes of 58 patients who were treated with thermotherapy. MAIN OUTCOME MEASURES Tumor response and ocular adverse effects. RESULTS Of 188 retinoblastomas treated with thermotherapy, mean tumor base was...

iris recognition is one of the most reliable methods for identification. in general, itconsists of image acquisition, iris segmentation, feature extraction and matching. among them, iris segmentation has an important role on the performance of any iris recognition system. eyes nonlinear movement, occlusion, and specular reflection are main challenges for any iris segmentation method. in this pa...

 Abstract Background: Transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. This study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. Methods: In a ...

E yes with small pupils present a challenge to cataract surgeons. A pupil that fails to dilate can obscure visualization during all stages of phacoemulsification, making surgery more difficult and increasing the incidence of complications such as nucleus drop, vitreous prolapse, and iris tear. Inadequate pupil dilation is often seen in patients with a history of use of miotic agents, chronic uv...

Background: A number of ocular biometric parameters, iris hiotologic and anatomic characters have been suggested as inciting factors for converting patients with narrow angle to angle-closure glaucoma. This study was conducted to determine if there was any goniscopic difference between patients with acute angle-closure glaucoma (AACG) and chronic angle-closure glaucoma (CACG). Methods: ...