Abstract BACKGROUND Although the initial response to immune-checkpoint inhibition (ICI) for patients with DNA replication-repair deficient high-grade glioma (RRD-HGG) is encouraging, role of immune-based salvage approaches those progressing on anti-PD1 monotherapy unknown. METHODS We performed an international registry study managed using central molecular, genomic, radiological review and trea...

abstract. vegetation of each region is one of the most important phenomena of nature and is the best guide to judge about the ecological sciences of that region because the plants are resistant organisms that have endured the long term conditions of all kinds of environmental conditions for a long period of time and have adapted with environmental stresses. therefore floristical investigation o...

the dehdasht bauxite deposits are located 40 km northeast of dehdasht in kohgilouye and boyer-ahmad province. it is a part of the irano-hymalayan karstic bauxite belt located in the upper part of karstic depressions of santonian-turonian sarvak carbonate formation. the aim of this study is to determine various geneses of pisoliths and prevalent processes in bauxitization. for this purpose, labo...

iran has a long history in the use of medicinal plants and traditional medicine. local people in the villages, especially the elderly, have useful information about health benefits and how to use these plants. therefore, it seems that collecting and recording this information leads to the revival of this traditional knowledge. the current research is an ethnobotanical study on the medicinal pla...