Objective-To measure the amounts of interleukin-1 receptor antagonist (IL-Ira) protein produced by cultured synovial cells obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods-Synovial cells obtained from patients with either RA or OA were cultured and the supernatants were measured for IL-lra by enzyme linked immunosorbent assay. Results-The synovial celis obt...

IRA is a Fortran library that solves the shape matching problem for atomic structures, stored as sets of points representing positions. In case exact- and near-congruence, provides optimal rigid transformation between given by assignments, rotation/reflection matrix, translation vector. also able to operate on structures containing non-equal number atoms, i.e. structure any its fragments. Any a...

Disease-related research requires a different kind of teamwork, says Ira Mellman. He hopes to find that team at his new home at Genentech.

Let F (m; n1, n2) denote the number of lattice walks from (0, 0) to (n1, n2), always staying in the first quadrant {(n1, n2); n1 ≥ 0, n2 ≥ 0} and having exactly m steps, each of which belongs to the set {E = (1, 0),W = (−1, 0), NE = (1, 1), SW = (−1,−1)}. Ira Gessel conjectured that F (2n; 0, 0) = 16 (1/2)n(5/6)n (2)n(5/3)n . We pose similar conjectures for some other values of (n1, n2), and gi...

Context: Late intervention to open an occluded infarct-related artery (IRA) after initial acute myocardial infarction was postulated to lead to clinical benefi t. Objective: To conduct a meta-analysis of the randomized trials. Study selection: Eligibility criteria were: 1) randomized trials comparing percutaneous coronary intervention (PCI) in a totally occluded artery (TIMI fl ow 0-1) versus m...

OBJECTIVE The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and uric acid (UA) are inflammatory markers in cardiovascular disease. However, there are not enough data on infarct-related artery (IRA) patency in ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the association of NLR, PLR, and UA with IRA patency before percutaneous coronary inte...

OBJECTIVE We investigated the impact of the severity of stenosis in a non-infarct-related artery (IRA) on the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS Three hundred one consecutive patients (age: 59.7 ± 13.2 years, 85.5% men) underwent primary PCI during 2009-2012. Receiver oper...

OBJECTIVE The aim of this study was to determine the accuracy of exercise echocardiography (EE) for detecting infarct-related artery (IRA) stenosis and predicting functional recovery early after acute myocardial infarction (AMI). BACKGROUND Dobutamine stress echocardiography is widely used for identifying jeopardized myocardium. The clinical usefulness of a biphasic response detected during E...

OBJECTIVES To investigate dual-phase multi-detector computed tomography (MDCT) for assessing extent and severity of jeopardised and infarcted myocardium subtended by infarct-related artery (IRA), and its indication for revascularisation after acute myocardial infarction (AMI). Designs, setting and PATIENTS Prospective, single-centre study included 107 patients with uncomplicated post-AMI 3-7 ...