Somatodendritic dopamine (DA) release in the substantia nigra pars compacta (SNc) shows a limited dependence on extracellular calcium concentration ([Ca(2+)](o)), suggesting the involvement of intracellular Ca(2+) stores. Here, using immunocytochemistry we demonstrate the presence of the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) that sequesters cytosolic Ca(2+) into the endopl...

The ryanodine receptor 1 (RyR1) is the major skeletal muscle Ca 2+ release channel and as such a key player in excitation-contraction coupling. Intriguingly, a recent paper reported RyR1 fragmentation 24 h after high-intensity interval exercise (six 30-s all-out cycling bouts with 4 min recoveries in between) in vastus lateralis muscle biopsies taken from recreationally active men (Place et al....

This paper presents a method for the veriication of speed-independent circuits. The main contribution is the reduction of the circuit to a set of complex gates that makes the veriication time complexity depend only on the number of state signals (C elements, RS ip-ops) of the circuit. Despite the reduction to complex gates, veriication is kept exact. The speciication of the environment only req...

This paper presents a method for the veriication of speed-independent circuits. The main contribution is the reduction of the circuit to a set of complex gates that makes the veriication time complexity depend only on the number of state signals (C elements, RS ip-ops) of the circuit. Despite the reduction to complex gates, veriica-tion is kept exact. The speciication of the environment only re...

Standard webmetrics tools record the IP address of users’ computers, thereby providing fodder for analyses of their geographical location, and for understanding the impact of e-learning and teaching. In this paper, we describe how two web-based educational systems were engineered to collect georeferenced data. This is followed by a description of joining these data with demographic and educatio...

Generic Simulator was developed in order to provide a common framework for generating simulation software which are used to test communication interfaces used by the software units developed for various projects. This paper evaluates the design and usage of Generic Simulator Software which provides a framework that defines common message definition templates for various interfaces and protocols...

Mice overexpressing CB2r (CB2xP) were exposed to open field (OF), light-dark box (LDB) and elevated plus maze (EPM) tests. Corticotropin-releasing factor (CRF) and pro-opiomelanocortin (POMC) mRNA were measured in paraventricular (PVN) and arcuate (ARC) nuclei of the hypothalamus after 30 minutes of restraint stress (RS). Anxiolytic effects of alprazolam (45 or 70 µg/kg, ip) were evaluated. GAB...

Chronic administration of sibutramine lowers body weight, presumably by altering brain monoamine metabolism. Here the effect of sibutramine on sympathoadrenal function (24-h urine norepinephrine and epinephrine levels) and arcuate nucleus (ARC) neuropeptide Y (NPY) and proopiomelanocortin (POMC) expression was assessed in diet-induced obese rats fed a low-fat diet. Chronic (10 wk) sibutramine [...