■ CONTENTS Basic Ion Mobility Concepts 1423 Electrostatic and Electrodynamic Fields 1423 Resolving Power 1423 Ion Mobility Techniques 1424 Temporally-Dispersive Ion Mobility 1424 Drift Tube Ion Mobility Spectrometry (DTIMS) 1425 Traveling Wave Ion Mobility Spectrometry (TWIMS) 1426 Overtone Mobility Spectrometry (OMS) 1427 Confinement and Mobility-Selective Release 1428 Trapped Ion Mobility Spe...

BACKGROUND Alzheimer's disease (AD) is diagnosed based upon medical history, neuropsychiatric examination, cerebrospinal fluid analysis, extensive laboratory analyses and cerebral imaging. Diagnosis is time consuming and labour intensive. Parkinson's disease (PD) is mainly diagnosed on clinical grounds. OBJECTIVE The primary aim of this study was to differentiate patients suffering from AD, P...

A combined untargeted and targeted approach was established for fingerprinting volatile organic compounds in winter jujubes from eight regions of China. Volatiles, including alcohols, aldehydes, acids, esters, alkenes, were identified by gas chromatography-ion mobility spectrometry (GC-IMS). Benzyl alcohol, octanoic acid, 2-hexenal, linalool, 2-nonenal, ethyl decanoate the most common present a...

Volatile organic compounds (VOCs) produced during microbial fermentations determine the flavor of fermented food and are of interest for the production of fragrances or food additives. However, the microbial synthesis of these compounds from simple carbon sources has not been well investigated so far. Here, we analyzed the headspace over glucose minimal salt medium cultures of Saccharomyces cer...

Gangliosides (GGs), a particular class of glycosphingolipids ubiquitously found in tissues and body fluids, exhibit the highest expression in the central nervous system, especially in brain. GGs are involved in crucial processes, such as neurogenesis, synaptogenesis, synaptic transmission, cell adhesion, growth and proliferation. For these reasons, efforts are constantly invested into developme...

In the pharmaceutical industry, there are increasing requirements for analytical methods in quality assessment for the production of drugs. In this investigation, ion mobility spectrometry (IMS) was used for the rapid qualitative separation and identification of active ingredients in generic over-the-counter drugs and food additives in beverages. The active ingredients determined in drugs were ...

A novel analogue of sibutramine, 11-desisobutyl-11-benzylsibutramine, has been discovered. During routine ion mobility spectrometry (IMS) screening of a weight loss supplement collected at an US FDA import operation facility an unknown peak was observed. Further analysis of the supplement by liquid chromatography-mass spectrometry (LC-MS) and high resolution mass spectrometry revealed an unknow...

The injection and ionization of volatile organic compounds (VOA) by an integrated chip is experimentally analyzed in this paper. The integrated chip consists of a needle-to-cylinder electrode mounting on the Polymethyl Methacrylate (PMMA) substrate. The needle-to-cylinder electrode is designed and fabricated by Lithographie, Galvanoformung and Abformung (LIGA) technology. In this paper, the nee...

’ INTRODUCTION Since the development of electrospray ionization for mass spectrometry (MS), several MS-based approaches have been developed for characterizing structures of gas-phase protein ions. These can be categorized as either chemical or physicalmethods. Chemical methods include: ion ion and ion molecule reactions, detection of noncovalent adducts, 9 and monitoring of hydrogen/deuterium (...