A method aimed at poten charged ionophores in ion surements of segmented s of ion association requires ment of the sandwichmu ionophore complexationm evaluated. Association of Experimental results are with commonly used sites bis[4-(1,1,3,3-tetramethyl

Cyclo(L-Lac-L-Val-D-Pro-D-Val)3 (PV-Lac) a structural analogue of the ion-carrier valinomycin, increases the cation permeability of lipid bilayer membranes by forming a 1:1 ion-carrier complex. The selectively sequence for PV-Lac is identical to that of valinomycin; i.e., Rb+ greater than K+ greater than Cs+ greater than or equal to NH+4 greater than Na+ greater than Li+. The steady-state zero-...

Introduction: Nowadays, the use of heavy ion beams in cancer therapy have been developed worldwide.   Materials and Methods: It requires accurate understanding of the complex processes of ion interaction with matter, as it is the calculation the relative dose & range of these ions in matter. In the present study we used FLUKA as a numerical Monte Carlo simula...

The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT3 (5-hydroxytryptamine; 5-HT3 receptors), glycine and GABA (gamma-aminobutyric acid; GABAA receptors). A vast knowledge of the structure of the Cys-loop superfamily and its impact on channel function have been accrued over the last few years, leading to exc...