AIMS We aimed to evaluate the prognostic value of routine use of PCR amplification of immunoglobulin gene rearrangements in bone marrow (BM) staging in patients with follicular lymphoma (FL). METHODS Clonal rearrangements were assessed by immunoglobulin heavy and light-chain gene rearrangement analysis in BM aspirates from 96 patients diagnosed with FL and related to morphological detection o...

BACKGROUND Although nail psoriasis affects a substantial proportion of psoriasis patients and causes significant psychologic distress, few epidemiologic data characterizing patients with nail involvement are available. The aim of this research was to elucidate differences between patients with nail psoriasis and those without any nail involvement, taking quality indicators of health care from t...

Introduction Juvenile dermatomyositis (JDM) is a rare condition affecting 3 children/million/year. Muscle and skin involvement are key features. The muscle symptoms are frequently the main initial focus: formal measures (CMAS and MMT8) exist to routinely and accurately assess this component of the disease. However the involvement of skin, and its assessment, is also a vital aspect. The abbrevia...

Patients with tracheal involvement from primary or secondary neoplasms usually present with relatively nonspecific symptoms of cough, wheeze, and shortness of breath. Prompt diagnosis often requires a high index of suspicion. Tomography or computed tomography of the chest will often confirm the presence of a tracheal lesion. A detailed rigid bronchoscopic assessment by an experienced thoracic s...

1. A short critical review of the role of serotonin in predatory attack is given. 2. Among factors determining the degree and Wee of psychopharmacological involvement are: species, drug, and dependent behavioral measure chosen as a representative index of predation. 3. One factor which may limit the actual involvement of serotonin is response non-specificity, i.e. the generalized disinhibition ...

Correct use of an adrenalin auto-injector (AAI) is vital in an emergency situation where a person has gone into anaphylactic shock. Studies have shown that nearly half of untrained participants are unable to correctly use an AAI training device after instruction. Emerade is an AAI with a different design for use, with pictures providing instructions. This study aimed to assess intuitiveness and...

Henoch-Schoenlein purpura (HSP) is a vasculitis of the small blood vessels with clinical presentation of a multi-organ involvement syndrome at variable expression in derma, intestine, articulations and kidney. Firstly identified by Heberden, Schoenlein described the purpuric and articular manifestations and Henoch the gastrointestinal and renal features. The combination of various systemic and ...

Over the last two decades, important advances have been made in explaining some pathophysiological aspects of heart failure with preserved ejection fraction (HFpEF) with repercussions for the successful clinical management of the syndrome. Despite these gains, our knowledge for the natural history of clinical progression from the pre-clinical diastolic dysfunction (PDD) until the final clinical...

There is no doubt that ionising radiation damages DNA and that certain organs in the body are more vulnerable than others to the effects of radiation. However, the reasons for the different sensitivities vary and there are now known to be many late expressed effects of exposure that cannot simply be explained on the basis of direct DNA damage. Examples include transmissible genomic instability,...

the present research was conducted with the aim of exposition of the relationship between organizational climate and job involvement among teachers of high schools in delijan city of iran in year (2012-2013). the research was applied, descriptive and correlational.statistical population included184 teachers in the first semester of educational year (2012- 2013), of which 125 teachers were selec...