For past many years, strategies for the preclinical discovery and development of potential anticancer agents have been based largely upon the testing of agents in. selected animals bearing transplantable tumors. The feasibility of implementing combined in vitro/in vivo screening for selective cytotoxicity among panels of human tumor cell lines derived from a broad spectrum of human carcinomas h...

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis performed by using KOH 40% under stirring at room temperature for 48 h. compounds characterized FTIR, GC-MS 1H NMR spectrometers. Further, the chalc...

Floating drug delivery systems are mainly expected to remain buoyant in gastric contents and consequently enhance the bioavailability of drugs Microsphere is loaded with a their outer polymer shells was prepared by novel emulsion-solvent diffusion method. It floated continuously over surface acidic dissolution media containing surfactant for invitro time 12 hours. microspheres ofloxacin were o/...

BACKGROUND AND PURPOSE Candidaalbicans is the most common causative agent of candidiasis. Candidiasis management is dependent on the immune status of the host, severity of disease, and the choice of antifungal drug. Antifungals, specifically triazoles, are widely administered for the treatment of invasive fungal infections. Herein, we aimed to evaluate the invitro susceptibility of C.albicans i...

Objectives: To determine the isolation rate of Alternaria alternata in patients with clinical Onychomycosis Study Design: Descriptive (cross sectional) study Place and Period of Study: Department of Microbiology, Armed Forces Institute of Pathology Rawalpindi, from August 2011-April 2012. Material and Methods: Sample size; 200 nail samples, Sampling Technique; Non probability convenience sampli...

Stirred, pH-controlled anaerobic batch cultures were used to investigate the in vitro effects of galacto-oligosaccharides (GOS) alone or combined with the probiotic Bifidobacterium bifidum 02 450B on the canine faecal microbiota of three different donors. GOS supported the growth of B. bifidum 02 450B throughout the fermentation. Quantitative analysis of bacterial populations by FISH revealed s...

The present study evaluate the anti-inflammatory activity of petroleum ether extract, ethanolic extract and aqueous extract of ocimum sanctum Linn (karunthulasi leaves). Extract was carried out using soxhlet apparatus. These three extract were subject to phytochemical analysis in order to find out the constituents present in the sample. Secondly, HRBC membrane stabilization was selected for fur...

The plant Acmella Paniculata commonly known as Akala Kara belonging to family of Asteraceae mainly found in tropical and subtropical regions around the world. Annual herb grown upto 30 cm tall with pungent taste. All parts of this plant are being used to traditional medicine to treat various diseases. Pet ether, chloroform, ethyl acetate and methanol extracts from whole plant of Acmella Panicul...

Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity.Human breast tumor cell lines are needed for multidisciplinary research in breast cancer.In the laboratory breast cancer is often modelled using ...