Abstract Invariant Natural Killer T (iNKT) cells are characterized by a semi-invariant TCR and NK markers. They respond to glycolipid antigens presented the major histocompatibility complex (MHC)-like molecule CD1d. Our single-cell transcriptomic profiling of several tissues identified marrow iNKT as unique subset, possibly modulating homeostasis. However, little is known about their role in he...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...