It is now 10 years since the first case reports of the use of intravenous lipid emulsion (ILE) as treatment for local anaesthetic systemic toxicity (LAST). In spite of very scarce data on efficacy, safety and mechanism of action, this novel therapy was enthusiastically adopted by anaesthesiologists, clinical toxicologists and emergency medicine physicians worldwide. However, recent thoroughly p...

I T seems implausible that an injection of a simple, off-theshelf, intravenous nutritional solution could be acutely life-saving for a patient with severe drug overdose. But dozens of published case reports support this observation, first made more than a decade ago in a rodent model of bupivacaine toxicity. It is even more surprising that such a simple formulation can rapidly reverse severe cl...

BACKGROUND Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity. MATERIAL/METHODS In this single-blinded randomized control stud...