Catalytic antibodies are immunoglobulins endowed with enzymatic activity. Catalytic IgG has been reported in several human autoimmune and inflammatory diseases. In particular, low levels of catalytic IgG have been proposed as a prognostic marker for chronic allograft rejection in patients undergoing kidney transplant. Kidney allograft is a treatment of choice for patients with end-stage renal f...

Currently, COVID-19 is one of the most pressing healthcare problems across world. With no definitive pharmacological guidelines, multiple drugs were used to treat critical patients with little success. Tocilizumab, a monoclonal antibody has shown some role in treatment Covid-19 infection. The study was cross-sectional prospective observational study. It conducted Intensive Care Unit (ICU) Liaqu...

BACKGROUND Hashimoto's encephalopathy (HE) is a rare autoimmune syndrome characterized by various neuropsychiatric manifestations, responsive to steroid treatment and associated with Hashimoto's thyroiditis. There are only a few reports suggesting that intravenous immunoglobulins (IVIG) might represent an efficacious treatment modality for the severe steroid-resistant HE cases. We presented a p...

Sir, Livedoid vasculopathy manifests in the form of painful, recurrent ulcers on the lower limbs. The condition is mainly found in young and middle-aged women (1). Histologically, the disorder is characterized by the presence of hyaline thrombi in the cutaneous microcirculation. The underlying pathogenesis is not known, although local or systemic alterations in coagulation control appear to be ...

BACKGROUND Peripheral neuropathy is a prominent feature of the systemic and secondary vasculitides. Usually, it is responsive to corticosteroids, but in certain cases it may be resistant to corticosteroid or immunosuppressive treatment, or both. OBJECTIVE To present patients who exhibited various inflammatory diseases accompanied with vasculitic peripheral neuropathies for which intravenous i...

Immunoglobulins (antibodies) are plasma proteins produced by B cells, which are essential in the defence against bacterial and viral infections. Dysregulation of the immune system can lead to the formation of autoantibodies and subsequent autoimmune disease. Therapy with immunoglobulin was first studied in the late 19th century, when Von Behring and Kitasato showed that serum taken from rabbits...

1Department of Internal Medicine and 2Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Descartes, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France. Benjamin Terrier, MD; Achille Aouba, MD; Boris Bienvenu, MD, PhD; Coralie Bloch-Queyrat, MD, PhD; Emmanuelle Delair, MD; Jasmina Mallet, MD; Alfred Mahr, MD, PhD; Loïc Guillevin, MD. B. Terri...

Copyright: © 2013 Osada SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Successful Treatment of Intravenous Immunoglobulins in a Patient with Intractable Epidermolysis Bullosa Acquisita with Autoant...

The association of chronic inflammatory demyelinating polyneuropathy (CIDP) and carcinoma has rarely been reported and its relevance is debated. Thirty three consecutive patients with probable or definite CIDP (idiopathic or associated with M protein) were investigated. Three patients with definite CIDP had a concomitant carcinoma. One had an IgM paraprotein. Steroids and intravenous immunoglob...

We report a case of Guillain-Barré syndrome associated with an acute, disseminated toxoplasmosis due to a new and unknown zymodeme (zymodeme 12) in an immunocompetent patient. The patient's condition improved with pyrimethamine and sulfadiazine. Only the standard treatment for toxoplasmosis was effective, whereas intravenous immunoglobulins were ineffective.