BACKGROUND Intrathecal administration of acetylcholinesterase inhibitors produces antinociception in both animals and humans, but their effect on diabetic neuropathic pain has not been studied. In the current study, we determined the antiallodynic effect of intrathecal injection of an acetylcholinesterase inhibitor, neostigmine, in a rat model of diabetic neuropathic pain. In addition, since ac...

BACKGROUND Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS After approval of the institutional review board and the Food and Drug Administra...

OBJECT In this study, we aimed to investigate the beneficial effects of dexmedetomidine on somato-visceral sensory block characteristcs, postoperative analgesia and stress response of intrathecal bupivacaine administration in women undergoing cesarean section, and to find out which dose is better. METHODS Sixty parturients with the American Society of Anesthesiologists (ASA) physical status I...

In order to reveal some cytotoxic features of lidocaine, the effects of lidocaine at sublethal concentrations (10 mM or less) on rat thymocytes were examined by the use of flow-cytometric technique with fluorescent probes. Treatment with lidocaine at 3-10 mM for 1-3 hr significantly increased intracellular Ca and Zn concentrations under normal condition. After the removal of external Ca and Zn,...

BACKGROUND Topical anesthetics are commonly applied for a variety of indications. Several lidocaine-containing topical anesthetics are available for purchase over the counter (OTC). Recently, the authors' group has shown that there is great interindividual discrepancy in the manner in which lidocaine is absorbed and metabolized for even a single OTC product. OBJECTIVES The authors compare fiv...

This study assessed the effect of low (10 mg ⋅ kg-1 ⋅ h-1) and very high (18 mg ⋅ kg-1 ⋅ h-1) doses of lidocaine on defibrillation energy requirements (DER) to relate changes in indexes of sodium-channel blockade with changes in DER values using a dose-response study design. In group 1 (control; n = 6 pigs), DER values were determined at baseline and during treatment with 5% dextrose in water (...

OBJECTIVE To evaluate intravenous lidocaine's safety and efficacy as an analgesic agent in the treatment of a variety of painful conditions presenting to the emergency department. METHODS This case series identified seventeen patients who received lidocaine over a six month period and recorded demographic data, amount of lidocaine administered, the amount of opioid medication administered bef...

BACKGROUND Pain on injection of rocuronium is a common clinical problem. We compared the efficacy of lidocaine, ketorolac, and the 2 in combination as pretreatment for the prevention of rocuronium-induced withdrawal movement. METHODS For this prospective, randomized, placebo-controlled, double-blind study a total of 140 patients were randomly allocated to one of 4 treatment groups to receive ...

Objective- This study was performed to investigate the analgesic effects of lidocaine and lidocaine/tramadol combination in epidural anaesthesia in dromedary camels. Design- Experimental Study Animals- Eight healthy immature dromedary camels Methods - The camels were randomly designed in 2 equal groups. In group L: lidocaine 2% (0.22 mg/kg) and in group LT: a combination of lidocaine 2% (0.22 m...