The maternal plasma concentration of bupivacaine has been determined in 19 patients receiving a continuous epidural block during labour, using bupivacaine 0.125% with adrenaline 1:400,000. The plasma concentration of bupivacaine rarely exceeded 0.18 /*g/ml. Bupivacaine does not accumulate in the maternal blood when such low concentrations are used. The plasma concentration of bupivacaine has al...

BACKGROUND Although spinal bupivacaine may have too long duration to be useful in the ambulatory setting, recent animal data suggest that lidocaine added to spinal bupivacaine may reduce the duration of bupivacaine spinal anesthesia. We explored whether lidocaine added to spinal bupivacaine could shorten the duration of bupivacaine spinal anesthesia in humans similarly to what has been reported...

BACKGROUND The median effective dose (ED50) of a drug gives the amount or dose of drug needed to produce effective therapeutic response or desired effect in at least 50% of the population taking it. Our study focused on determining the ED50 required for effective motor block using hyperbaric and plain bupivacaine, and evaluated the influence of baricity on the ED50 required for motor block. MAT...

objective: the goal of this study is to evaluate the efficacy of intraperitoneal (jp) cisplatin as consolidation treatment, in epithelial ovarian cancer patients with pathologically negative surgical reassessment, following first-line platinum-based chemotherapy. methods: this study included 22 patients with figo stage (iic- iv) epithelial ovarian cancer (eoc) which had no evidence of disease a...

The relative potency of lignocaine, bupivacaine and etidocaine was estimated by forearm skin weals in four volunteers. Potency was estimated as the time to half-recovery of a sharp sensation in response to a needle-prick. The increase in duration of action with increased concentration was greater for bupivacaine and etidocaine as compared with lignocaine. At the same concentrations, bupivacaine...

BACKGROUND The goal of this in vitro study was to investigate the effect of lipid emulsion on vasodilation caused by toxic doses of bupivacaine and mepivacaine during contraction induced by a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), in an isolated endothelium-denuded rat aorta. METHODS The effects of lipid emulsion on the dose-response curves induced by bupivacaine o...

BACKGROUND The current study examined the role(s) of autophagy in myotoxicity induced by bupivacaine in mouse myoblast C2c12 cells. METHODS C2c12 cells were treated with bupivacaine. Myotoxicity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (n = 3 to 30), live/dead assay (n = 3 to 4), and morphological alterations (n = 3). Autophagosome formation was refl...

OBJECTIVE To evaluate and compare the characteristics of spinal block, its postoperative analgesic effects and side effects using intrathecal bupivacaine and its combination with fentanyl or buprenorphine in elderly patients undergoing urological surgery. METHODS Sixty patients aged sixty and above scheduled for elective transurethral resection of prostate (TURP) randomly received hyperbaric ...

BACKGROUND Local vasoconstriction induced by epinephrine added to epidural local anaesthetics has been shown to improve their quality and duration of action in several clinical reports. There are several assumptions on the mechanisms. This study was designed to evaluate the influence of epinephrine on transmeningeal uptake of epidurally administered ropivacaine and bupivacaine by measuring loca...

A 24-year-old female with a history of ulcerative colitis underwent colectomy. The patient received an ineffective transversus abdominis plane (TAP) block with liposome bupivacaine (Exparel) intraoperatively and was started on a hydromorphone patient-controlled analgesia 5 hours after the TAP block, which did not relieve her pain. A continuous thoracic epidural (CTE) was then placed after blood...