PURPOSE Determine acceptance of and compliance with intranasal cobalamin (vitamin B12) replacement therapy. METHODS Veteran subjects were recruited from VA Outpatient facilities in Hawai'i. Information was obtained by interview and medical record review. Subjects received the standard dose of intranasal cobalamin of 500 micrograms intranasally, once a week. A follow-up questionnaire was admin...

Although the blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for the use of systemically administered therapies, an alternative approach, the non-invasive method of intranasal delivery, can rapidly target delivery of molecules to the CNS. Intranasal delivery has the distinct advantages of circumventing the BBB while minimizing systemic exposure. This novel approac...

Of several newer delivery systems under development and investigation for the administration of opioids, the intranasal route has received a substantial amount of attention. Intranasal administration is a convenient form of delivery that is applicable to several opioids. It has the potential for self-administration, combined with a rapid onset of action, allowing for patient-controlled analgesi...

Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospective cohort study based on the medical records of 19 stroke patients presenting with status epilepti...

pemphigus vulgaris (pv) is often complicated by osteoporosis. although corticosteroid therapy undoubtedly plays a causative role, inflammation associated with pv may also contribute to osteoporosis. this study was designed to determine the prevalence of osteoporosis in patients with pv before corticosteroid therapy and to compare these findings with those reported previously in healthy voluntee...

a b s t r a c t a few case reports of coinfections with nocardia and mycobacterium tuberculosis (tb) have previously been published in the literature. we report on a case of concomitant pulmonary nocardiosis and tuberculosis, in a recently diagnosed 55-year-old woman, with rheumatoid arthritis, who had been taking a short course of a low dose corticosteroid. the patient was treated with a combi...

background: osteonecrosis (on) is known to be one of the most disabling complications following corticosteroid (cs) medications. however, evidence regarding risk of asymptomatic prevalence of on among different diseases and the impact of variable steroid regimens are conflicting. we aimed to determine the prevalence of on of femoral head in asymptomatic patients with systemic rheumatic diseases...

Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal al...

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is one of the most difficult forms of CRS to treat and exhibits frequent recurrence regardless of therapeutic modality (1). Current consensus guidelines support longterm medical treatment with intranasal corticosteroid (INCS) sprays, supplemented with short, infrequent courses of oral corticosteroids. Several reviews have systematically exami...