The clinical presentation hypopigmentation is a rare complication after intralesional injection of triamcinolone acetonide. A 32-year-old female, yellow race, visited our dermatology department for a hypopigmented patch in right dorsum of her right thumb. The lesion developed after injection of an intralesional corticosteroid. The patient was diagnosed with hypopigmentation secondary to the tri...

Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under in vitro and in vivo models, in inbred BALB/c mice. Methods: Different concentrations of bo...

BACKGROUND In most of the reported series, almost half of the giant-cell tumors involved the knee region. The characteristics of the lesions were usually benign but often locally aggressive and easily recurrent neoplasms. Some surgeons performed intralesional excision combined with local adjunctive chemical coagulant, and bone grafting or methylmethacrylate cement packing. These methods could b...

Objective: To evaluate the effectiveness of intralesional bleomycin in comparison to cryotherapy treatment cutaneous warts. Method: The randomized controlled trial was conducted at Department Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January July 2021, and comprised patients either gender aged 18-60 years who had warts for 1-48 weeks. subjects were divided into group A trea...

Background: Leishmaniasis is a vector-borne disease that causes skin infections around the world through bite of sand fly. This leads to formation cutaneous leishmaniasis and scars on area cosmetically significant. Objective: Our study aimed evaluate efficacy intralesional metronidazole (5%) in comparison with intralesionalmeglumineantimonate treatment leishmaniasis. Methods: In current 40 pati...

Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (H...

BACKGROUND Sensitive and glucantime (MA) resistance Leishmania tropica are referred to those isolates, which are responsive, or non-responsive to one or two full courses of treatment by MA systematically and/or intra-lesionally, respectively. In this study, we evaluated the antileishmanial activity of biogenic selenium nanoparticles (Se NPs) alone and in combination with MA against sensitive an...

BACKGROUND/AIM There are different modalities for management of infantile hemangiomas (IHs). In this report, our aim is to evaluate whether intralesional corticosteroid treatment is associated with systemic side effects and whether this is an effective treatment modality for IH. MATERIALS AND METHODS Six children treated with intralesional corticosteroids for problematic hemangiomas were incl...

BACKGROUND A giant cell tumor is a benign locally aggressive tumor commonly seen in the distal radius with reported recurrence rates higher than tumors at other sites. The dilemma for the treating surgeon is deciding whether intralesional treatment is adequate compared with resection of the primary tumor for oncologic and functional outcomes. More information would be helpful to guide shared de...

Background: Wart is a common skin disease, and 8% of patients referred to dermatologists suffer from warts. Objective: To compare the efficacy of intralesional injections of bleomycin with normal saline in treatment of common resistant warts on palms and dorsum of hands. Patients & Methods: This study was a double blind, randomized, controlled clinical trial on 34 patients with common war...