Mouse models are commonly used for studying hepatocellular carcinoma (HCC) biology and exploring new therapeutic interventions. Currently three main modalities of HCC mouse models have been extensively employed in pre-clinical studies including chemically induced, transgenic and transplantation models. Among them, transplantation models are preferred for evaluating in vivo drug efficacy in pre-...

a case o f intrahepatic stone and its t r eat ment i s present e d . the t ype s o f i ntrahepatic s tones , t h e etiological f act o r , t he ways of di agno s is and t reatment a re b eing discussed. the disease is common in far eastern c ountri es a nd asian are a, with c lonorchi s s i nens is inf estation, but s peci ally in iran when the s tones i s a lone in intrahepatic ducts without e...

BACKGROUND ABCB4/MDR3 gene variants are mostly associated with a peculiar form of cholelithiasis in European adults, currently referred to as low phospholipid-associated cholelithiasis (LPAC) syndrome. METHODS LPAC syndrome is a rare genetic disorder, characterised by the following clinical features: biliary symptoms before the age of 40, recurrence of the symptoms after cholecystectomy, and ...

background & aim:combretaceae family is   known for efficacy in the management of sickle cell disorder (scd). based on   the earlier reports of anti-sickling property of terminalia genus the study investigates in vitro antisickling properties of terminalia arjuna and terminalia   bellirica. experimental: anti-sickling   assay of methanolic and aqueous extract of t. arjuna and t. bellirica   on ...

An acquired membrane defect is believed from the incubation buffer, ISCs are not to be responsible for the maintenance of generated despite metabolic depletion. the sickled shape in oxygenated irreversThis suggests an action of ATP mediated ibly sickled cells ( ISC) , because the hemothrough calcium metabolism similar to globin S in these cells is not in the aggrethat which prevents membrane st...

BACKGROUND Interferon-alpha (IFN-α), an active cytokine, plays an important role in antiviral host responses, including protection against hepatitis B virus (HBV) infection. This study was designed to investigate the correlation between intrahepatic IFN-α expression levels and disease severity using liver biopsy specimens from HBV-infected patients with different outcomes. PATIENTS AND METHOD...