BACKGROUND Trials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) in acute anterior wall myocardial infarction treated wi...

AIMS Stem cell therapy after myocardial infarction (MI) has been studied in models of permanent coronary occlusion. We studied the effect of intracoronary administration of unselected bone marrow (BM) and mononuclear cells (MNC) in a porcine model of reperfused MI. METHODS AND RESULTS In 34 swine, the left circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. Ten sw...

Infarct size limitation has been a therapeutic aim for many years, particularly in view of the known close relationship between the extent of myocardial damage occurring at the time of the infarction, and future morbidity and mortality. It is only in the last decade, however, since the pathophysiology of myocardial infarction has been better understood, that this aim has become a clinical reali...

Intracoronary ECG was invented in 1974 and in 1985 it was shown for the first time that intracoronary wire could be used as an ECG unipolar lead to detect ongoing ischemia in humans. Intracoronary ECG still remains highly underused technique for guiding percutaneous coronary interventions. This article summarizes studies dating from 1974 through 2016 showing intracoronary ECG usefulness in find...

www.interventional.theclinics.com Intracoronary Imaging and Its Use in Interventional Cardiology April 2023 • Volume 12 Number 2 Editor YASUHIRO HONDA

BACKGROUND Intracoronary transfer of autologous bone marrow cells (BMCs) may enhance recovery of left ventricular (LV) function in patients after acute myocardial infarction (AMI). However, clinical studies addressing the effects of BMCs after AMI have covered only limited time frames ranging from 3 to 6 months. The critical question of whether BMC transfer can have a sustained impact on LV fun...

[2] Fishman DL, Leon MB, Bairn DA et al. A randomised comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994; 331: 496-501. [3] Colombo A, Hall P, Nakamura S el al. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance. Circulation 1995; 91: 1676-88. [4] Monce MC, Zemour G, Benven...

OBJECTIVES The study sought to determine the incidence and predictors of late total occlusion (LTO, >30 days) in-patients with in-stent restenosis who were treated with intracoronary radiation. BACKGROUND Intracoronary radiation both with beta and gamma emitters has been shown to reduce recurrent in-stent restenosis. METHODS We reviewed the records of 473 patients who presented with in-sten...

AIM to assess the safety and feasibility of combined granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) based intracoronary peripheral blood stem cells (PBSCs) therapy in patients with recent myocardial infarction (RMI) who had successful reperfusion therapy with drug-eluting stent. METHODS a total of 18 patients diagnosed with anterior ST-segment elevation AMI who had suc...

OBJECTIVES The purpose of this study was to examine the effect of intracoronary radiation therapy (IRT) in diabetic patients with in-stent restenosis (ISR). BACKGROUND Diabetic patients are at an increased risk for restenosis, repeat revascularization procedures and late mortality after percutaneous coronary interventions and stenting. Intracoronary radiation therapy, utilizing both gamma and...