The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the formation of R-loops, co-transcriptional RNA-DNA products, which in some instances have been link...

Immunological research of steroid-depended chemical carcinogenesis in humans is based on positive experience the clinical usage selective estrogen receptor modulators and experimental design immunological methods for human protection from environmental carcinogens. Our study aimed idiotypic antibodies against benzo[a]pyrene, estradiol progesterone (IgA1-Bp, IgA1-E2 IgA1-Pg), connection with ant...

The branching ratio of the structure dependent (SD) radiative $K^{+} \to e^{+} \nu_{e} \gamma$ decay relative to that $K^+\rightarrow e^+ (\gamma)$ including internal bremsstrahlung (IB) process ($K_{e2(\gamma)}$) has been measured in J-PARC E36 experiment using plastic scintillator/lead sandwich detectors. In analysis, effect IB was also taken into account SD as $K_{e2\gamma(\gamma)}^{\rm SD}$...

El mango cv. Tommy Atkins es cultivado en el departamento del Tolima, principalmente, lugar donde expresa su mejor comportamiento agronómico y calidad de la fruta. objetivo fue evaluar estado nutricional las plantas cuantificar extracción nutrientes por fruta función orden suelo se cultiva. Las concentraciones cada nutriente variaron entre fases muestreadas órgano (hojas, flor fruto) (Entisol e...

Ubiquitin (Ub) signaling requires the covalent passage of Ub among E1, E2, and E3 enzymes. The choice E2 enzymes combined with multiple rounds cascade leads to formation polyubiquitin chains linked through any one seven lysines on Ub. linkage type length act as a signal trigger important cellular processes such protein degradation or DNA damage response. Recently, proteomics studies have identi...

Estradiol (E2) circulates in the blood in three states: unbound (U-E2), bound to sex-hormone binding globulin (SHBG-E2), and bound to albumin. There is evidence to support the concept that only U-E2 and albumin-bound E2, are bioavailable (i.e., rapidly extracted by tissues). A case-control study nested within a large cohort of women, in which we are examining the effect of estrogens on breast c...

statement of the problem: a major objective of investigators is to clarify the role of metabolites in achievement of maximum tooth movement with minimal root damage during orthodontic tooth movement (otm). purpose: the aim of this study was to determine the effect of administration of thyroid hormone, prostaglandin e2, and calcium on orthodontic tooth movement and root resorption in rats. mater...

The E2 envelope glycoprotein is the primary target of human neutralizing antibody response against hepatitis C virus (HCV), and is thus a major focus of vaccine and immunotherapeutics efforts. There is emerging evidence that E2 is a highly complex, dynamic protein with residues across the protein that are modulating antibody recognition, local and global E2 stability, and viral escape. To compr...

In this work, the some collective properties of even-even Ti isotopes in A50 mass region were studied by using interacting boson model-1 (IBM-1). This study includes calculations energy levels and electromagnetic transition rates 44-48Ti 52-60Ti isotopes. The neutron number 50Ti isotope is 28, magic number, was excluded from IBM-1 calculations. First, ratios analyzed comparing typical values U...