Ketamine is a non-competitive glutamatergic antagonist used to induce sedation and analgesia. In sub-anesthetic doses, it induces hyperlocomotion, impairs memory and evokes stereotypic circling in rodents. Zebrafish (Danio rerio) emerged as a promising new animal model to screen the effects of psychotropic compounds. Here, we investigated the effects of sub-anesthetic doses of ketamine on anxie...

Realignment of the hip knee and ankle can be achieved by extra-articular osteotomy if there is no intra-articular deformity or incongruity. Intra-articular osteotomy of the femoral head, femoral condyles, tibial plateaus and tibial plafond can all be achieved technically and biologically and lead to a congruous joint. This is a new frontier for realignment surgery extending the indications for ...

An outbreak of methicillin-susceptible Staphylococcus aureus joint infections occurred at an outpatient radiology center. We identified 7 case patients; all had undergone magnetic resonance arthrograms with intra-articular joint injections. The outbreak was likely due to unsafe injection practices in preparation of contrast solution for intra-articular injection.

PURPOSE The purpose of this study was to report clinical results of open excision of extra-articular ganglion cysts around the knee joint combined with arthroscopic management of intra-articular pathologies if present. MATERIALS AND METHODS Of the total 107 cases of cystic lesions around the knee, 23 cases of extra-articular ganglion cysts were reviewed between January 2006 and July 2011. The...

OBJECTIVES The goal of this study was to determine whether intra-articular administration of the potentially anti-fibrotic agent decorin influences the expression of genes involved in the fibrotic cascade, and ultimately leads to less contracture, in an animal model. METHODS A total of 18 rabbits underwent an operation on their right knees to form contractures. Six limbs in group 1 received f...

As one of the many causes groin pain, iliopsoas tendinitis can be hard to identify and even harder treat. It occurs in setting both native hip joint following total arthroplasty. Internal snapping, or coxa saltans, result from snapping over anterior capsule iliopectineal eminence a source labral pathology. The painful painless. Iliopsoas impingement components either cup collar femoral stem are...

Intra-articular fractures can produce degenerative changes causing continued pain and disability, therefore optimal surgical care might be indicated. Metatarsal (MT) intra-articular are no exception. While prior literature described mainly of the first MT lateral toes, there is scarce addressing second head, which longest most robust bone. In this case series, we report three cases head fractur...

Lornoxicam (Lnxc), a novel type of non-steroidal antiinflammatory drug developed by comely, was first listed in Denmark in October 1997 (trade name xefo). Clinically, it is used to treat rheumatoid, rheumatoid arthritis and osteoarthritis. The Lnxc with low drug concentration has a short half-life [1] after oral administration, leading to much side effect and therapy activity tended to be worse...

BACKGROUND Intra-articular injection of hyaluronic acid (HA) is a well-documented treatment for knee osteoarthritis (OA). One of the multifactorial mechanisms is that exogenous HA can stimulate endogenous HA production. HA can regulate the growth and function of chondrocytes by binding to CD44 receptors on the chondrocytes. Synovitis is often found in patients with rheumatoid arthritis (RA) and...