Background: Colorectal cancer is the second leading cancer-related death worldwide and a majority of patients die from metastasis. Chronic intestinal inflammation plays an important role in tumor progression of colorectal cancer. However, few study works on systematically predicting colorectal cancer metastasis using inflammatory cytokine genes. Results: We developed a supervised machine learni...

Specificity protein 1 (SP1) is an essential transcription factor that regulates multiple cancer-related genes. Because aberrant expression of SP1 is related to cancer development and progression, we focused on SP1 expression in gastric carcinoma and its correlation with disease outcomes. Although patient survival decreased as SP1 expression increased (P<0.05) in diffuse-type gastric cancer, the...

AIMS To assess whether standard and variant isoforms of CD44 (CD44s, CD44v5, and CD44v6) have a differential expression profile in early versus advanced gastric adenocarcinoma of the diffuse and intestinal types and their metastases. METHODS Immunohistochemical expression of CD44s, CD44v5, and CD44v6 was evaluated in 14 early gastric cancers (nine intestinal and five diffuse) and 37 advanced ...

Pulmonary veno-occlusive disease (PVOD) is an uncommon in humans and animals caused by pulmonary hypertension (PH). The aim of this study was to investigate pathomorphological findings PVOD a cat. A mass detected the right atrium with echocardiography 11-year-old male Following treatments, necropsy cat performed after death due respiratory failure. Macroscopically, masses were mesenteric lymph ...

hepatoblastoma (hb) is a rare tumor of infancy and childhood manifesting with hepatomegaly and abdominal distention. it is seen with increased frequency in association with congenital hemihypertrophy and renal anomalies. metastases to other organs, including the lungs, lymph nodes and even ovaries is well known. but cerebral metastasis of this tumor, especially in the absence of metastasis to o...