We set out IDR as a loglinear model-based Moran’s I test for Poisson count data that resembles the Moran’s I residual test for Gaussian data. We evaluate its type I and type II error probabilities via simulations, and demonstrate its utility via a case study. When population sizes are heterogeneous, IDR is effective in detecting local clusters by local association terms with an acceptable type ...

This research was conducted to determine the financial feasibility of growing soybean varieties and their competitiveness in rice-based cropping system Indonesia. The at two locations 2020. results showed that use improved yielded 2.24 t/ha 2.09 t/ha, which higher than using local (non-improved) varieties. financially feasible with Revenue Cost (R/C) ratios 1.88–1.98 Benefit (B/C) 0.88–0.98. so...

Dissecting the mechanism of action of surface-tethered antimicrobial and immunomodulatory peptides is critical to the design of optimized anti-infection coatings on biomedical devices. To address this, we compared the biomembrane interactions of host defense peptide IDR-1010cys (1) in free form, (2) as a soluble polymer conjugate, and (3) with one end tethered to a solid support with model bact...

Eukaryotic cells contain membrane-less organelles, including nucleoli and stress granules, that behave like liquid droplets. Such endogenous condensates often have internal substructure, but how this is established in the absence of membrane encapsulation remains unclear. We find that the N- and C-terminal domains of TDP43, a heterogeneous nuclear ribonucleoprotein implicated in neurodegenerati...

ARTICLE HISTORY Received 2 June 2017 Accepted 14 June 2017 ABSTRACT Synaptotagmin 1 (Syt 1) is an integral membrane protein responsible for sensing the calcium ion (Ca2C) influx in neurons that triggers synaptic vesicle exocytosis. How Syt 1’s intrinsically disordered region (IDR), a »60 residue sequence located between the protein’s transmembrane helix and two Ca2C-sensing C2 domains, contribu...

Seismic isolation systems for buildings design are not as popular in the seismically active developing countries they developed ones. Several factors contribute to this, namely lack of knowledge on benefits seismic systems, unfamiliarity with procedure, and absence relevant building codes that provide guideline using system such countries. Recently, Indonesian code has been updated included str...

There is a possibility of increasing structural damage in the sequential earthquake compared to main according past earthquakes. This study investigates effects seismic sequence on behavior and increased response reinforced concrete frames (RCF) with/without steel plate shear walls (SPSW). Four systems 4, 8, 12, 24 story, which represent low-, mid-, high-rise structures, are designed subjected ...

The control of vibrations and damage in traditional reinforced concrete (RC) buildings under earthquakes is a difficult task. It requires the use innovative devices to enhance seismic behavior buildings. In this paper, we design RC with buckling restrained braces (BRBs) achieve objective. For aim, three framed structures 3, 6, 9 story levels are designed by using well-known technique nondominat...

BACKGROUND Only a few prospective studies have determined which clinical symptoms and factors are associated with the disease severity of spinocerebellar ataxia type 6 (SCA6). A multicenter longitudinal cohort study was conducted to clarify both the natural history of SCA6 in Japan and the factors influencing disease progression. METHODS Patients were consecutively recruited between 2007 and ...