We examined loss of heterozygosity in 49 adenocarcinomas and 18 squamous cell carcinomas of the lung with 19 RFLP markers on the short arm of chromosome 3. Although no interstitial deletions were observed in any squamous cell carcinomas, interstitial or partial deletions were detected in 23 adenocarcinomas. Identification of two common regions of deletion in adenocarcinomas, at 3p21.3 and 3p 14...

PURPOSE To report the treatment effect of interstitial brachytherapy for chest wall locoregional recurrence of breast cancer. MATERIAL AND METHODS This 44-year-old female presented with chest wall recurrence seven years after modified radical mastectomy for stage II breast cancer. Despite external beam radiation and chemotherapy, the lesion expanded as 5.3 × 5.1 × 3.0 cm(3), and 8.0 × 5.1 × 4...

background and aims: plants as medicines have always played a vital role in human life. tumor necrosis factor alpha (tnf)-α is one of the macrophage-derived inflammatory cytokine with pleotropic effects in the inflammation process. some studies have been demonstrated that some of the echinops species have anti-inflammatory activity. in fact, echinops lasilepis is introduced as one of the native...

objective: recent evidences suggest that tumors arise from a small subpopulation of cells, the cancer stem cells (cscs) or tumor initiating cells. cscs are able to resist the conventional methods of cancer therapy due to existence of abc transporters on their surface. this leads to csc resistance and maintenance resulting in post-treatment relapse and metastasis. therefore, precise identificati...

background: although giant cell tumor (gct) is considered to be a primary benign bone tumor, its aggressive behavior makes its diagnosis and treatment, difficult and challenging. this is especially true in distal radius where gct appears to be more aggressive and difficult to control locally. we report our clinical outcome of en-block resection and reconstruction with non-vascularized fibular a...

objective(s): the oct4b1, as one of oct4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. the present study was designed to determine the effects of oct4b1 silencing on expressional profile of hsp40 gene family expression in three different human tumor cell lines. materials and met...

Steroid biosynthesis was studied in a spontaneous mouse interstitial cell tumor grown as a transplant in isologous male recipients. In timed incubations the tu mor tissue rapidly transformed dehydroepiandrosterone to androstenedione. The formation of testosterone, 11/îhydroxyandrostenedione, and 11/3-hydroxytestosterone proceeded at a slower rate. A conversion product with Chromatographie char...

Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma challenging. Focus is shifting towards using proximal fluids for biomarker discovery, but methods to verify the isolated sample's origin are missing. We therefore aimed to develop...

Most research on the resistance of cancers to chemotherapy has concentrated on molecular mechanisms of resistance, whereas the role of limited drug distribution within tumors has been neglected. One critical obstacle to the success of anticancer therapies, especially to chemotherapy, radiotherapy and immunotherapy, is related to the inefficient distribution of drugs or oxygen to cancer cells. T...

Desmoplastic small round cell tumor is a rare malignant tumor that occurs primarily in young males. Here, a case of small round cell tumor in an adult male successfully treated with a curative concurrent chemoradiotherapy is presented. A 58-year-old man had an intrapelvic tumor. Surgical resection was attempted, but the tumor was unresectable. Needle biopsy was performed and the diagno...