the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

objective: bleaching of the teeth is considered as a safe, effective, and conservative procedure to treat discolored teeth. the aim of the present study was to compare the amount of mercury and silver released from amalgam after applying two brands of carbamide peroxide 16% bleaching gel. materials and methods: for this experimental study, 384 amalgam tablets were prepared. the samples were kep...

Whilst there has been a recent appreciation for the role of open-system pingos in providing fluid-flow conduit through continuous permafrost that enables methane release, formation and internal structure these ubiquitous permafrost-diagnostic landforms remains unclear. Here, we combine active-source seismic measurements with electrical resistivity tomography to investigate structural subsurface...

In this study, the energy release rates in a centrally perforated star-shaped disk, which was made of a polymeric material, under internal pressure and thermal loads, were determined. The deformations of the disk were constrained by a circular steel ring enclosing the disk. Two constitutive models, namely, Hookean model and Ogden model, were used to model the constitutive behavior of the materi...

Paclitaxel is an antimicrotubule agent that induces mitotic block and apoptosis. We show for the first time that paclitaxel acts directly or mitochondria isolated from human cancer cells. In isolated yeast mito chondria, paclitaxel (15 microM) induced an 18% increase in the respiration rate, with no concomitant release of cytochrome c. In isolated neuroblas toma mitochondria, paclitaxel (10-100...

the present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. the procedure consists of the increase of the aqueous gelatin solution to the non-solvent phase containing lutherol f127. three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. the mor...