gastroesophageal reflux disease (gerd)  is defined with clinical symptoms  of  heart burning and regurgitation. it may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. in the present study, rats with chronic aspiration of gastroduodenal contentswere studied for  cellular phenotypes  and  cytokine c...

fully mature dendritic cells (dcs) play pivotal role in inducing immune responses and converting naïve t lymphocytes into functional th1 cells. we aimed to evaluate listeria monocytogenes-derived protein fractions to induce dc maturation and stimulating t helper (th)1 immune responses. in the present study, we fractionated listeria monocytogenes-derived proteins by adding of ammonium sulfate in...

It is commonly recognized that proinflammatory cytokines in patients with multiple sclerosis (MS) may increasingly cause inflammation. In this regard, the current study was aimed to shed light on the effectiveness of eight-week Pilates training program at interleukin-18 (IL-18) stage, severity of fatigue and balance as well as physical disability in females with MS. This study was a quasi-exper...

adult periodontitis is a complex multifactorial disease whose etiology is not well defined. the pro-inflammatory and bone resorption properties of interleukine-1α (il-1α) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. eighty iranian adult patients with periodontitis and 80 iranian controls were investigated in this study. in this study we report that the f...

Objective: To evaluate the pattern of pro-inflammatory cytokines, anti-inflammatory cytokines and the acute phase response (APR) as markers of the response to treatment of pulmonary tuberculosis. Methods: Twenty-eight patients with pulmonary tuberculosis were evaluated at three time points: pretreatment (T0), treatment month 3 (T3) and treatment month 6 (T6). Levels of interferon-gamma (IFN-γ),...

OBJECTIVE This study sought to identify the relationship between fibroblast telomerase expression, myofibroblasts, and telomerase-mediated regulatory signals in idiopathic pulmonary fibrosis. METHODS Thirty-four surgical lung biopsies, which had been obtained from patients with idiopathic pulmonary fibrosis and histologically classified as usual interstitial pneumonia, were examined. Immunohi...