recently, inflammation has been found to be a significant factor in the development of schizophrenia (scz). the aim of the present research was to investigate whether interleukin-33 (il-33, omim: 608678) gene polymorphism (rs11792633, c/t) is associated with the development of scz or not.dna was isolated from the serum of 70 patients with scz and 70 healthy controls. the pcr based method was us...

Abstract Background: A major impact of the IL28B gene polymor-phism on response to antiviral therapy in chronic hepatitis C have been described recently by a lot studies. This study aims scrutinize genotypes donors and recipients treatment with INF based or DAA among patients that underwent liver trans-plantation. Aim Study: correlate genotype for had undergone transplantation therapy, Direct A...

BACKGROUND Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited. AIM We analyzed the...

Aim. We analyzed the pretreatment natural killer (NK) cell functions with the aim of predicting the sustained virological response (SVR) or the interleukin (IL) 28B polymorphism that is strongly associated with the treatment response. Methods. The peripheral NK cells from chronic hepatitis patients with HCV genotype 1 and high virus titers were activated using a Toll-like receptor (TLR) 4 ligan...

BACKGROUND AND RATIONALE Age is one of the predictors for sustained virological response (SVR) when treating chronic hepatitis C (CHC) patients with pegylated-interferon/ribavirin (PegIFN/RBV). However, the treatment responses of the young patients had not been analyzed before. Therefore, we conducted this study to investigate the treatment responses of CHC patients younger than 40 years old (y...

Single nucleotide polymorphisms of interleukin-28B (IL28B) rs8099917 are reported to be associated with virologic clearance in interferon-and ribavirin -based treatment for hepatitis C virus (HCV)-infected patients. We examined virologic response in accordance with IL28B polymorphisms in our living donor liver transplantation series under a preemptive interferon and RBV treatment approach. Adeq...

With the aim of investigating whether interleukin 28B gene (IL28B) rs1297860 polymorphism is associated with different hepatitis C (HCV) infection statuses, we compared IL28B allelic distribution in an Italian case series of 1050 patients with chronic infection and different outcomes, 47 individuals who spontaneously cleared HCV, and 178 blood donors. Furthermore, we compared IL28B variants amo...

BACKGROUND Hepatitis C virus genotype 4 (HCV-4) is the most prevalent genotype in Central Africa. AIM To compare epidemiology, clinical characteristics and any differences in access to HCV therapy in two populations of HCV-4 patients residing in Belgium. METHODS This multicenter study selected 473 HCV-4 patients from seven hospital databases and compared them according to ethnic origin, i.e...