To investigate the effects and mechanism of sphingosine-1-phosphate/sphingosine-1-phosphate receptor on pro-angiogenesis in human colon cancer cells is main objective. The sphingosine-1-phosphate HT-29 SW480 were assessed by tube formation assay. Quantitative real-time polymerase chain reaction was used to detect expression interleukin-8, interleukin-6 vascular endothelial growth factor HT29 af...

Introduction: COVID-19 is a new type of coronavirus that infects humans and causes severe acute respiratory syndrome (SARS). Isolated in Wuhan City, China, December 2019. Similar to discoveries relating the coronaviruses cause (SARS-CoV) Middle East (MERS-CoV). Levels cytokines (Interleukin-6, Interleukin-1 β ), iron hemoglobin changed during disease. Hepcidin an regulatory protein encoded by H...

henoch–schönlein purpura (hsp), a common allergic hemorrhagic disease, occurs frequently in children affecting kidney, joint and skin. while interleukin-8 (il-8) plays an important role in inflammation, the association between il-8 gene +781 c/t polymorphism and hsp remains unclear. interleukin-8, an important chemokine related to the initiation and amplification of acute inflammatory responses...

Rheumatoid arthritis (RA) is a common disease of unknown aetiology which usually causes progressive destruction of the joints. Familial aggregation, twin studies and segregation analyses suggest that there is a genetic component to RA and the HLA-DRB1 locus in the major histocompatibility complex on chromosome 6 has been shown to be linked to, and associated with, RA susceptibility. It is likel...

Apolipoprotein A-IV is a member of the apo A-I/C-III/A-IV gene cluster. In order to investigate its hypothetical coordinated regulation, an acute phase was induced in pigs by turpentine oil injection. The hepatic expression of the gene cluster as well as the plasma levels of apolipoproteins were monitored at different time periods. Furthermore, the involvement of the inflammatory mediators' int...

Sequence analysis of cloned plant disease-resistance genes reveals a number of conserved domains. Researchers have used these domains to amplify analogous sequences, resistance gene analogs (RGAs), from soybean and other crops. Many of these RGAs map in close proximity to known resistance genes. While this technique is useful in identifying potential disease resistance loci, identifying the fun...

To investigate the efficacy of linezolid in treatment pulmonary tuberculosis combined with severe pneumonia and its effect on prognosis. 72 patients were selected our hospital random divided into control observation group. Patients both groups first received basic symptomatic treatment. On this basis, group was given isoniazid injection intravenously while glucose as an adjunctive treated conti...

The present study was conducted to investigate the effects of dietary fermented cottonseed meal (FCSM) substitution for fish on intestinal enzymatic activity, inflammatory and physical-barrier-related gene expression, microflora juvenile golden pompano. 375 pompanos were divided into 15 groups 25 each, with three replicates each experimental group. fed five diets (0 (FM), 12.5% (CSM12.5), 25% (...