Interferons and interleukin-10 are involved in key aspects of the host defence mechanisms. Human chromosome 21 harbors the interferon/interleukin-10 receptor gene cluster linked to the GART gene. This cluster includes both components of the interferon alpha/beta-receptor (IFNAR1 and IFNAR2) and the second components of the interferon gamma-receptor (IFNGR2) and of the IL-10 receptor (IL10R2). W...

Interferon stimulated gene 15 (ISG15) is one of the most highly upregulated proteins in response to viral infection and involved numerous pathways with multiple mechanisms actions. ISG15 deficiency has been reported induce type I interferonopathy owing defective negative regulation IFN-I signalling as well enhanced antiviral protection. Here, we have generated knockout clones from human iPSCs, ...

The time-sequential change in immune-related gene expression of the glioblastoma cell line after irradiation was evaluated to speculate effect combined immunotherapy with radiotherapy. U373 MG irradiated 6 Gy single dose. Next-generation sequencing (NGS) transcriptome data generated before (control), and at 6, 24, 48 h post-irradiation. Immune-related pathways were analyzed each time period. sa...

Macrophages secrete various cytokines and inflammatory mediators, resulting in playing critical roles inflammation immunity. In this study, we investigated anti-inflammatory immune enhancing properties of PB203, which is a water-soluble extract powder from the fruit Actinidia polygama, macrophages. A. polygama medicinal plant traditionally known to treat abdominal pain, stroke rheumatoid arthri...

Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added ad...

Candida infections are common infections and fluconazole is one of the most frequently administered antifungal agents in their treatment. The resistance developed against antifungal agents has necessitated the improvement of new treatments. This study focuses on the investigation of the effect of fluconazole and cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-al...

A whole-blood model was used to evaluate the effects of temperature and anticoagulant on the expression of activation markers HLA-DR and CD11b on peripheral leukocytes. Venous blood, anticoagulated with either EDTA or heparin, was obtained from six healthy blood donors and 13 hospitalized patients (8 human immunodeficiency virus type 1-seropositive individuals with concurrent pulmonary tubercul...

Interferon-induced gene expression was analyzed in wild-type and interferon-resistant Daudi cells. Two classes of alpha-interferon-induced mRNAs and proteins were observed: those that were similarly induced in both types of cell and those that were induced only in the wild-type cells. Furthermore, the level of c-myc mRNA decreased in the wild-type but not in the resistant cells. This differenti...