نتایج جستجو برای: interferon lambda 3 ifnl3
تعداد نتایج: 1887303 فیلتر نتایج به سال:
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral properties in a similar manner to type I IFNs. However, while IFNλ has been described to have largely overlapping expression and function with typ...
AIMS Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict the treatment outcome for patients with HCV. Furthermore, SNPs in newly discovered IFNL4 are shown to have population-specific correlation with spontaneous clearance of HCV. The aim of this study was to examine the prevalence and clinical significance of the outlined SNPs...
فضاهای فشرده و لیندلوف از فضاهای اساسی در مطاله ی توپولوژی هستند که تا به حال به طور مجزا مطالعه شده اند. در این پایان نامه با تعریف $lambda$-فشردگی هر دو فضا را با یک خاصیت مشترک در نظر می گیریم که وقتی $lambda$ برابر با $aleph_{circ}$ است؛ فضای فشرده و وقتی که $lambda$ برابر با $aleph_1$ است؛ فضای لیندلوف نافشرده به دست می آید.فضای $lambda$-فشرده را تعریف کرده و نشان داده ایم که...
background macrophages play critical roles in innate immune response in the liver. whether macrophages participate in liver innate immunity against hcv replication is poorly understood objectives the aim of this study was to investigate the role of macrophages in liver innate immunity against hcv replication. conclusions macrophages may play an important role in liver innate immunity against hc...
The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group. Type III IFN is structurally similar to type II IFN (IFN-γ) but functionally identical to type I IFN (IFN-α/β). However, in contrast to type I or type II IFNs, the r...
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-λ has therapeutic potential ...
in this paper, we consider the following kirchhoff-type equations: $-left(a+bint_{mathbb{r}^{3}}|nabla u|^{2}right)delta u+v(x) u=lambda$ $f(x,u)+u^{5}, quad mbox{in }mathbb{r}^{3},$ $u(x)>0, quad mbox{in }mathbb{r}^{3},$ $uin h^{1}(mathbb{r}^{3}) ,$ where $a,b>0$ are constants and $lambda$ is a positive parameter. the aim of this paper is to study the existence of positive ...
The spatially varying tensor fields that arise in magnetic resonance imaging are difficult to visualize due to the multivariate nature of the data. To improve the understanding of myocardial structure and function a family of objects called glyphs, derived from superquadric parametric functions, are used to create informative and intuitive visualizations of the tensor fields. The superquadric g...
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