In radiation therapy, especially using intensity modulated radiation therapy (IMRT), a high dose of ionizing radiation is delivered to the patient and, therefore, the bone health is a major concern for young patients. What is more, many tumors, like soft tissue sarcomas, are located in close proximity to bone. High energy radiation unavoidably exerts negative impacts not only on bone physiologi...

BACKGROUND Concurrent chemotherapy and radiation therapy is the preferred standard of care for patients with anal cancer. Several studies have suggested a benefit of intensity-modulated radiation therapy (IMRT) compared with 3D-conformal radiation (3D-CRT) regarding acute toxicity. This study evaluates outcome and toxicity of patients undergoing IMRT/Tomotherapy or 3D-CRT at our institution. ...

PURPOSE To report the results of a prospective study that compares small bowel doses during prone and supine pelvic intensity modulated radiation therapy. METHODS AND MATERIALS Ten patients receiving pelvic radiation therapy each had 2 intensity modulated radiation therapy plans generated: supine and prone on a belly board (PBB). Computed tomography on rails was performed weekly throughout tr...

Introduction A literature review was conducted to establish if intensity modulated radiation therapy (IMRT) planning and treatment enhances current whole pelvic radiation therapy (WPRT) practices for early-stage gynaecological malignancies. Our purpose was to determine if IMRT implementation at a small radiation therapy centre is feasible, and warranted, given the issues of potentially small pa...

BACKGROUND For patients with sarcomas, radiotherapy can be used as neoadjuvant, adjuvant, or primary local therapy, depending on the site and type of sarcoma, the surgical approach, and the efficacy of chemotherapy. METHODS The authors review the current status of advanced technology radiation therapy in the management of bone and soft tissue sarcoma. RESULTS Advances in radiotherapy have r...

An important issue in intensity modulated radiation therapy (IMRT) is the verification of the monitor unit (MU) calculation of the planning system using an independent procedure. Because of the intensity modulation and the dynamic nature of the delivery process, the problem becomes much more involved than that in conventional radiation therapy. In this work, a closed formula for MU calculation ...

BACKGROUND The purpose of this study is to report our clinical outcomes using intensity-modulated radiation therapy (IMRT) for adjuvant treatment of cervical cancer, compared with three-dimensional conformal radiation therapy (3DCRT), in terms of tumor control, complications and dose-volume histogram (DVH) parameters. METHODS Between March 2008 and February 2014, 62 patients were treated with...

M odern radiotherapy techniques for the treatment of squamous cell carcinoma (SCC) of the anus have led to a significant reduction in the incidence and severity of skin toxicity. However, grade 4 radiation dermatitis remains a difficult complication of radiation therapy for malignancies located in skin folds, a phenomenon known as the ‘‘bolus effect.’’ We describe a case of grade 4 radiation de...

CT: computed tomography HNCSCC: head and neck cutaneous squamous cell carcinoma IMRT: intensity-modulated radiation therapy MMS: Mohs micrographic surgery PNI: perineural invasion RT: radiation therapy SCC: squamous cell carcinoma INTRODUCTION Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a growing problem in the immunosuppressed population, and the behavior of these cancers can b...

The present work investigated the potential of compensator-based intensity-modulated radiation therapy (CB-IMRT) as an alternative to multileaf collimator (MLC)-based intensity-modulated radiation therapy (IMRT) to treat malignant pleural mesothelioma (MPM) post extrapleural pneumonectomy. Treatment plans for 4 right-sided and 1 left-sided MPM post-surgery cases were generated using a commercia...