BACKGROUND Guidelines recommend P2Y12 inhibitor therapy for 1 year after myocardial infarction (MI), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year. We describe changes in P2Y12 inhibitor type among patients with recurrent ischemic events in the first year after MI. METHODS AND RESULTS The TRANSLATE-ACS (Treatment With A...

BACKGROUND Comorbidity is often mentioned as interfering with "optimal" treatment decisions in diabetes care. It is suggested that diabetes-related comorbidity will increase adequate treatment, whereas diabetes-unrelated comorbidity may decrease this process of care. We hypothesized that these effects differ according to expected priority of the conditions. METHODS We evaluated the relationsh...

The impacts of environmental moisture on the intensification of a tropical cyclone (TC) are investigated in the Weather Research and Forecasting (WRF) model, with a focus on the azimuthal asymmetry of the moisture impacts relative to the storm path. A series of sensitivity experiments with varying moisture perturbations in the environment are conducted and the Marsupial Paradigm framework is em...

Mixed crop-livestock systems provide livelihoods for a billion people and produce half the world’s cereal and around a third of its beef and milk. Market orientation and strong and growing demand for food provide powerful incentives for sustainable intensification of both crop and livestock enterprises in smallholders’ mixed systems in Africa. Better exploitation of the mutually reinforcing nat...

Evidence suggests that there is variation in support for specific chicken farming practices amongst stakeholder groups, and this should be explored in more detail to understand the nature of these differences and work towards convergence. Online focus groups were used to assess attitudes to animal welfare in meat chicken farming in this pilot study. Across six online chats, 25 participants (gen...

BACKGROUND Basal insulin and premix insulin are commonly prescribed first-line insulin therapies for patients failing to maintain glycaemic control on oral therapy. When control on these insulins starts to drift, premix analogues, such as biphasic insulin aspart 30/70 (BIAsp 30), are a simple and effective tool for intensification as they can be injected up to three-times daily (TID). However, ...

Forecasting tropical cyclone (TC) intensification remains difficult despite research efforts to improve numerical weather prediction models. This study aims to examine Hurricane Earl’s rapid intensification in order to gain a better understanding of the observed and modeled intensification process. 113 dropwindsondes were analyzed before, during, and after RI in the eye, eyewall, and outer rain...

I analyzed a set of environmental and vegetation variables in order to characterize an intensification gradient for coffee production agroecosystems. I measured 14 habitat variables within 12 Colombian farms classified into four management systems at the Risaralda region of Colombia: Forests, Polygeneric Shaded coffee, Monogeneric Shaded coffee and Sun coffee plantations. The habitat variables ...

This clinical study, begun in 1975, tested the efficacy of early and delayed intensification treatments in children with acute lymphoblastic leukemia. Regardless of presenting features, all patients received 4 weeks of conventional induction therapy with daily prednisone and weekly vincristine and daunorubicin. One-third were randomized to receive, in addition, two doses of asparaginase during ...

Patients with resistant hypertension are at risk for poor outcomes. Medication adherence and intensification improve blood pressure (BP) control; however, little is known about these processes or their association with outcomes in resistant hypertension. This retrospective study included patients from 2002 to 2006 with incident hypertension from 2 health systems who developed resistant hyperten...