Gene expression is modulated by transcription factors (TFs), proteins that generally bind adjacent to DNA coding regions. The relation between these regulatory proteins and their targets is generally many to many; each target can be regulated by more than one TF, and each TF can contribute to the regulation of more than one target. Among the consequences of combinatorial regulation is the emerg...

The very short-period oscillations inevit,ably undergone by any meteorological quantity predicted by a system of primit’ive equations are principally noise, if an atmospheric model is designed so as to forecast a large-scale and slowly moving meteorological wave. The noise appears as highfrequency gravitational waves. In this paper the words “gravitational wave” will be used in this sense. It i...

In a short period of time, the World Wide Web has had a huge impact on our society and lives. In web sites and web applications, accessibility and usability are essential key requirements. Unfortunately, most web sites are inaccessible to many disabled people and fail to satisfy the most basic standards for accessibility. Many of the barriers people with disabilities face on the Web are complet...

We present a simple and accessible method which uses contour integration methods to derive formulae for functional determinants. To make the presentation as clear as possible, the general idea is first illustrated on the simplest case: a second order differential operator with Dirichlet boundary conditions. The method is applicable to more general situations, and we discuss the way in which the...

We propose methods to integrate data across several genomic platforms using a hierarchical Bayesian analysis framework that incorporates the biological relationships among the platforms to identify genes whose expression is related to clinical outcomes in cancer. This integrated approach combines information across all platforms, leading to increased statistical power in finding these predictiv...

Computing energy transfer between objects is the most expensive operation in radiosity systems. This energy transfer operation, known as the irradiance operator, is an integral that, in general, must be calculated numerically. We perform a study of numerical integration techniques to increase the speed of this computation without severely compromising fidelity. A theoretical discussion of numer...

In most cases unique identifiers are required to join data from different databases. If global unique keys are absent or corrupted the supplement of data extracted from different sources becomes difficult. The main question is: Does a given record is related to an entity which is identical to an entity corresponding to another record, or not? This leads to a classification problem with at least...

Formal methods can rarely capture all the dimensions of a software project. Diierent aspects of a project are thus typically formalized separately, with little or no integration. We study here the integration of a formal speciication methods and a validation method. The methods that we use are Larch and PROMELA/spin. Larch is an algebraic speciication method, specialized in the speciication of ...

Numerical integration methods are used to approximate the definite integral of a function. Various methods exist such as the Midpoint, Trapezoidal and Simpson Rules. The different methods that exist tend to offer a tradeoff between simplicity and accuracy. Simpson’s method is the most accurate of the aforementioned methods and is used in the LV2 INS calculations. Simpson’s method is one that as...

An integration between neurobiological and sociocognitive perspectives is advocated to advance and overhaul the concept of hypnosis and its humanistic applications. The thesis is presented that hypnosis is an altered state of brain functional organization involving interrelations between brain regions initiated by the intervention of the hypnotist – that is, an atypical alteration of brain syst...