Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g...

Fructose supplementation produced cardinal features of Syndrome-X including significant elevations in seum cholesterol, triglyceride, glucose and insulin and also in body weight. While treatment with methanolic extract of dried rhizomes of Zingiber officinale produced a significant reduction in fructose induced elevation in lipid levels, bodyweight, hyperglycemia and hyperinsulinemia, treatment...

context hcv infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. the aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis c virus (hcv) infection and insulin resistance (ir). we also explored the role of hcv core pro...

conclusions the mathematical meaning of the two insulin-related biomarkers examined was the same, and the odds ratios of the two biomarkers were almost the same after adjustments for other independent variables. objectives a one-year follow-up study was conducted to determine the ability of the insulin-related biomarkers to predict the risk of mets development. patients and methods a total of 2...

hyperglycemia and gestational diabetes mellitus are complications of pregnancy. both mothers and newborns are typically at increased risk for complications. this study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.in this clinical trial 44 pregnant women with imp...

the worldwide prevalence of insulin resistant states such as the metabolic syndrome has grown rapidly over the past few decades. the metabolic syndrome is a constellation of common metabolic disorders that promote the development of atherosclerosis and cardiovascular disease. studies in both human and animal models suggest that hepatic inflammation and insulin resistance are key initiating fact...

abstract bckground: patients with obstructive sleep apnea (osa) are at risk of developing the fatty liver as a result of being overweight. several studies suggest that osa per se could be a risk factor for liver injury and ischemic hepatitis with osa. the osa is an independent risk factor for insulin resistance. therefore, we investigated liver enzymes and insulin resistance in patients with os...

conclusions vitamin d repletion for 12 weeks increased serum vitamin d concentrations and improved β-cell activity in vitamin d-deficient type ii diabetes with no significant changes in hba1c or insulin sensitivity. results median [iqr] 25(oh)d levels increased significantly in the vitamin d group as 58.1 [48, 67.3] nmol/l (p = 0.002). there was no significant difference in the change of hba1c ...