This communication reports novel p-sulfonatocalix[4]arene thiol modified gold nanoparticles as a colorimetric sensor to probe lysine, arginine and histidine in water.

We describe the fabrication of a surface acoustic wave (SAW) atomizer, and show its ability to generate monodisperse aerosol and particles for drug delivery applications. In particular, we demonstrate the generation of insulin microdroplets for pulmonary delivery, and polymeric nanoparticles for one-step rapid encapsulation using SAW devices with resonance frequencies of 8.6 MHz and 19.3 MHz. I...

From recombinant insulin to monoclonal antibodies, proteins have become essential drugs in the therapeutic arsenal and respond a broad spectrum of diseases. While commercially available an extracellular activity, intracellular targets can be powerful alternative treat many pathologies such as cancers immune disorders, but also infectious Nevertheless, enter cell reach target organelle or molecu...

Alzheimer’s disease (AD) is the most prevalent form of dementia. Improving amount acetylcholine in brain an efficient way to treat illness. The global incidence dementia estimated be as high 50 million, and it expected increase every 20 years until 2040, resulting a costly burden disease. Early-life risk factors for pathology include genes, chromosomal abnormalities, head injury, insulin resist...

The aim of this study was to design and characterize solid lipid nanoparticles (SLNs) modified with stearic acid-octaarginine (SA-R₈) as carriers for oral administration of insulin (SA-R₈-Ins-SLNs). The SLNs were prepared by spontaneous emulsion solvent diffusion methods. The mean particle size, zeta potential, drug loading, and encapsulation efficiency of the SA-R₈-Ins-SLNs were 162 nm, 29.87 ...

The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed significantly decreased fasting blood glucose levels after 28 days of treatment. The serum insulin conce...

The cross-talk between beta cells and endothelium plays a key role in islet physiopathology and in the revascularization process after islet transplantation. However, the molecular mechanisms involved in this cross-talk are not fully elucidated. Extracellular vesicles (EVs) are secreted membrane nanoparticles involved in inter-cellular communication through the transfer of proteins and nucleic ...

objective: hyperglycemia is associated with increased morbidity and mortality in diabetic patients following coronary artery bypass grafting. tight glycemic control in perioperative period can reduce these events. the goal of this study was to determine whether combination of continuous infusion and subcutaneous glargine as a basal insulin could improve glycemic control. material and methods: d...