Diabetes is a non-communicable disease linked to reduced or diminished insulin levels, sensitivity, and mode of action. It can be easily defined as that affects the body’s ability produce adequate insulin.

results coincubation of islets with vitamin d (10 nm) and 11.1 mm glucose increased islet insulin release (37.27 ± 3.75 vs. 24.64 ± 2.83 ng/islet/24 hours; p < 0.05), while vitamin d (1 and 10 nm) decreased insulin release in the presence of 16.7 mm glucose (21.14 ± 3.58 and 18.65 ± 3.84 vs. 37.71 ± 4.63 ng/ islet/24 hours; p < 0.05). islets preincubation with vitamin d (1 and 10 nm) increased ...

microalbuminuria is thought to reflect the severity of inflammation-induced systemic vascular permeability. the present study investigated the effect of early administration of metformin or insulin on microalbuminuria in traumatized critically ill patients. between april 2006 and october 2007, thirty-one non-diabetics traumatized patients with systemic inflammatory response syndrome (sirs) and ...

insulin is currently the drug of choice in treating patients with gestational diabetes mellitus but insulin is expensive, inconvenient to store and use and probably associated with more risks of asymptomatic hypoglycemia in comparison with some oral agents. this randomized clinical trial was conducted to evaluate the efficacy and safety of glyburide in patients with gestational diabetes mellitu...

The effects of systemic insulin administration at different concentrations on the testicular tissue diabetic adult rats, induced by streptozotocin, are evaluated morphological analysis spermatogenic process. Twenty-four male rats were divided into 1) Control Group: they received citrate buffer, intraperitoneal injection; 2) Diabetic injection streptozotocin (60 mg. kg-1 body weight); 3) Insulin...

Insulin autoimmune syndrome or Hirata’s disease is an extremely rare condition leading to hypoglycaemia of variable severity due autoantibodies against insulin. We present the first case documented in Czech Republic.

Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g...